Additionally, curcumin increases energy expenditure in mouse models, either by facilitating white adipose tissue "browning," or by stimulating brown adipocyte UCP1
expression, dissociated from its anti-inflammation functions.
protein: The molecular hub of adipose organ plasticity.
Association studies on the porcine RETN, UCP1
, UCP3 and ADRB3 genes polymorphism with fatness traits.
Genipin is a chemical compound extracted from the gardenia plant, which could suppress UCP2 lead renal fibrosis properties by inhibiting the expression and activity of UCP2 and decrease reactive oxygen with the advantage that UCP1
, 3, 4, and 5 unaffected.
These mice had increased expression of thermogenic proteins (UCP1
and CIDEA), which favors the increase of energy expenditure, improvement of dyslipidemia due to increased fecal excretion of lipids, and reduction of de novo lipogenesis enzymes.
A study with ovariectomized rats indicated a reduction in UCP1
expression in brown adipose tissue and decrease in UCP2 expression in white adipose tissue, which may be associated with reduced energy expenditure and consequent increase in body mass (Pedersen et al, 2001).
In [NOV.sup.-/-] obese mice, there is a reduction in body weight, a decrease in expression of proinflammatory cytokines and chemokines, and increase in the levels of PGC-1[alpha] and UCP1
. In our obese mouse model, increased levels of HO-1 led to a concomitant reduction in NOV mRNA, as inflammation and markers of fibrosis to the levels of lean animals.
Collins, "[beta]-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1
) gene requires p38 MAP kinase," Journal of Biological Chemistry, vol.
Finelli et al., "The absence of polymorphisms in ADRB3, UCP1
, PPAR[gamma], and ADIPOQ genes protects morbid obese patients toward insulin resistance," Journal of Endocrinology Investigation, vol.
is primarily expressed in brown adipose, UCP2 is expressed across a wide variety of tissues, and expression of UCP3 appears to be limited to skeletal muscle and the heart .
Besides, our results also indicated that GPR43 expression in the differentiated brown adipocytes was much less (around 10-fold lower) than that in mature 3T3L1 cells (white adipocytes cell line) while the levels of UCP1
were significantly higher in immortalized brown adipocytes (Figures 1(b) and 1(c)), showing that the brown adipocyte precursor cells are successfully differentiated.
Uncoupling protein 1 (UCP1
) has been identified as a biological landmark of BAT that mediates nonshivering thermogenesis.