Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation
. J Invest Dermatol.
Therefore, the exposure of DOK cells to UVA radiation
decreased significantly CAT, GPX, and GR activities, and, to a lesser extent, the GST level.
Two models were created with ARESLab for constructing the time series of past UV yearly doses: one for the UVB and the other for the UVA radiation
. ARESLab uses training data cases with xt as input data and known outcome y, which is the measured daily UV dose.
UVB radiation, which has been associated with the induction of nonmelanoma skin cancer, is considered to be more carcinogenic than UVA radiation
. UVA radiation
is more abundant in sunlight and can penetrate deeper into the skin compared to UVB radiation.
High slopes and low intercepts are indicative of a stronger association of cutaneous melanoma with UVA radiation
. The lowest slopes of the regression models were computed for skin cancer incidence rates in 2000 and 2001 (a moderate decrease from 1999), followed by a rapid increase in 2002 and remaining elevated until 2007.
ORDINARY glass absorbs 97% of the UVB rays that cause sunburn and some skin cancers - but only 37% of UVA radiation
, responsible for ageing.
The products include a highly effective UVA/UVBA[degrees]filter system with TINOSORBS that provide excellent absorption capacity for three times more UVA radiation
, active ingredients like Licochalcone A, an antioxiA[degrees] dant, glycyrrhetinic acid which provides DNA protecA[degrees] tion as well as DNA repair.
On the other hand, UVA radiation
(320-400 nm, which is further divided into the two wave ranges of I: 340-400 nm and II: 320-340 nm), has deleterious synergy with the UVB segment, in addition to being capable, on its own, of inducing immunosupression (8, 10), photoaging (9, 12, 13), phototoxicity and photoallergic reactions (12, 13).
Experiments carried out with UVA radiation
showed a drop in blood pressure similar to that achieved by commercial drugs.
In issuing the guidelines, which follow up on proposed rules released four years ago, the FDA said that to earn the designation of offering "broad spectrum" protection sunscreens must protect equally against UVB and UVA radiation
“The ideal sunscreen should protect the skin against both UVB and UVA radiation
, and contain enzymes or other active ingredients that will stimulate DNA repair systems.”
But when you damage these cells with UVA radiation
, treatment with silibinin kills the cells," thus removing the mutated cells that can cause skin cancer and photo-aging, Agarwal said, according to a Colorado statement.