Superoxide dismutase; UPS, Ubiquitin-proteasome system
1]-expressing cells have a compromised ubiquitin-proteasome system, these cells are protected against oxidative stress conditions.
Because modification by Lys-48-linked polyubiquitin chains is known to serve as the essential means of targeting proteins for degradation by the ubiquitin-proteasome system, a failure of the UPS could play a role in tau accumulation in AD .
The ubiquitin-proteasome system
facilitates the transfer of murine coronavirus from endosome to cytoplasm during virus entry.
Essop, "HIV protease inhibitors and onset of cardiovascular diseases: a central role for oxidative stress and dysregulation of the ubiquitin-proteasome system
," Biochimica et Biophysica Acta (BBA)--Molecular Basis of Disease, vol.
This article focuses on three major proteolytic systems known to be affected by alcohol consumption--the lysosome, the ubiquitin-proteasome system, and the calpains.
The ubiquitin-proteasome system is now considered the major system involved in protein degradation within cells (for reviews of this system, see Bochtler et al.
VOLUME 1 Ubiquitin and the Chemistry of Life VOLUME 2 The Ubiquitin-Proteasome System
VOLUME 3 Cell Biology of the Ubiquitin-Proteasome System
VOLUME 4 Pathology of the Ubiquitin-Proteasome System
(Each volume contains a separate volume index.
Exercise training prevents oxidative stress and ubiquitin-proteasome system
overactivity and reverse skeletal muscle atrophy in heart failure," PLoS ONE, vol.
In their quest for a more representative model of PD, McNaught and colleagues took note of recent evidence that malfunction of the ubiquitin-proteasome system
is a central factor in both the rare hereditary and common sporadic forms of PD.
Chacinska, "The ubiquitin-proteasome system
regulates mitochondrial intermembrane space proteins," Molecular and Cellular Biology, vol.
Ciechanover, "Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system
and onto human diseases and drug targeting," Biochimica et Biophysica Acta--Proteins and Proteomics, vol.