ubiquitin

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ubiquitin

[yü′bik·wə‚tin]
(biochemistry)
A small, 76-amino-acid, highly conserved protein present in the cytoplasm and nucleus of all eukaryotes (but not eubacteria and archaea). The covalent, ATP-dependent linkage of multiple ubiquitin molecules to proteins serves as a signal for their degradation by the 26S proteasome.
References in periodicals archive ?
On the other hand, other authors (29,30) have shown that MuRF1 was associated with the ubiquitination and degradation of sarcomeric proteins, leading to a remarkable increase in proteolysis.
Findings have suggested that ubiquitination and related proteins play major roles in synaptic plasticity (2,3).
Although functional analysis exhibit miscellaneous posttranslational deformities, which lead to, gain of glycosylation and loss of ubiquitination at some peculiar amino acid residues.
RIP2 ubiquitination is regulated by a number of E3 ligases including various cellular inhibitor of apoptosis proteins (cIAPs) and TNF-receptor associated factors (TRAFs).
The first study, conducted in China, identified start-codon mutations in the KLHL24 gene in five patients, confirmed keratin 14 as the substrate of the protein, and established that KLHL24 mutations induce disproportionate ubiquitination and fragmentation of keratin 14.
This study, together with NIH's 2016 identification of haploinsufficiency of A20 (HA20), suggests a new category of human inflammatory diseases caused by impaired ubiquitination, according to the researchers.
Cullin-5 is a core component of Elongin-Cullin 2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [29].
12-19,24,25 These chaperones with the translocated Cx43 impair the nascent polypeptide chain structure of Cx43 with post- translational modifications such as glycosylation, phosphorylation, sulfation, acetylation, ubiquitination, ribosylation, C-terminal (glycosyl phosphatidyl inositol [GPI] membrane anchors) methylation.
DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

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