NEDD4-1 was shown to induce chemosensitization through ubiquitination
On the other hand, other authors (29,30) have shown that MuRF1 was associated with the ubiquitination
and degradation of sarcomeric proteins, leading to a remarkable increase in proteolysis.
Findings have suggested that ubiquitination
and related proteins play major roles in synaptic plasticity (2,3).
Although functional analysis exhibit miscellaneous posttranslational deformities, which lead to, gain of glycosylation and loss of ubiquitination
at some peculiar amino acid residues.
is regulated by a number of E3 ligases including various cellular inhibitor of apoptosis proteins (cIAPs) and TNF-receptor associated factors (TRAFs).
The first study, conducted in China, identified start-codon mutations in the KLHL24 gene in five patients, confirmed keratin 14 as the substrate of the protein, and established that KLHL24 mutations induce disproportionate ubiquitination
and fragmentation of keratin 14.
Stabilization of Mdm2 via decreased ubiquitination
is mediated by protein binase B/Akt-dependent phosphorylation.
EGCG also enhanced the ubiquitination
and proteasomal degradation of [beta]-catenin.
This study, together with NIH's 2016 identification of haploinsufficiency of A20 (HA20), suggests a new category of human inflammatory diseases caused by impaired ubiquitination
, according to the researchers.
Cullin-5 is a core component of Elongin-Cullin 2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediates the ubiquitination
and subsequent proteasomal degradation of target proteins .
12-19,24,25 These chaperones with the translocated Cx43 impair the nascent polypeptide chain structure of Cx43 with post- translational modifications such as glycosylation, phosphorylation, sulfation, acetylation, ubiquitination
, ribosylation, C-terminal (glycosyl phosphatidyl inositol [GPI] membrane anchors) methylation.
DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination