denaturation

(redirected from Undenatured)
Also found in: Medical.

denaturation,

term used to describe the loss of native, higher-order structure of proteinprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
..... Click the link for more information.
 molecules in solution. Most globular proteins exhibit complicated three-dimensional folding described as secondary, tertiary, and quarternary structures. These conformations of the protein molecule are rather fragile, and any factor that alters the precise geometry is said to cause denaturation. Extensive unfolding sometimes causes precipitation of the protein from solution. Denaturation is defined as a major change from the original native state without alteration of the molecule's primary structure, i.e., without cleavage of any of the primary chemical bonds that link one amino acid to another. Treatment of proteins with strong acids or bases, high concentrations of inorganic salts or organic solvents (e.g., alcohol or chloroform), heat, or irradiation all produce denaturation to a variable degree. Loss of three-dimmensional structure usually produces a loss of biological activity. Thus, the denatured enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
..... Click the link for more information.
 is often without catalytic function. Renaturation is accomplished with varying success, and occasionally with a return of biological function, by exposing the denatured protein to a solution that approximates normal physiological conditions. Denaturation may be studied in the laboratory in any number of ways that monitor the physical properties of protein. Thus measurements of changing viscosity, density, light-scattering ability, and movement in an electrical field all record slight changes in molecular architecture. Denaturing is also used to describe the unrelated process of adding a poisonous substance to ethanolethanol
or ethyl alcohol,
CH3CH2OH, a colorless liquid with characteristic odor and taste; commonly called grain alcohol or simply alcohol. Properties

Ethanol is a monohydric primary alcohol. It melts at −117.
..... Click the link for more information.
 to make it unsuitable for human consumption.
References in periodicals archive ?
Lonzas extensive health and nutrition portfolio features several clinically studied ingredients that address the latest consumer demands, including UC-II undenatured type II collagen, as well as Lonzas proprietary ResistAid ingredient.
Lonza's extensive health and nutrition portfolio features several clinically studied ingredients that address the latest consumer demands, including UC-II undenatured type II collagen, as well as Lonza's proprietary ResistAid ingredient.
The nutraceutical are also used for fish oil, methionine, olive oil, undenatured type II collagen and various other botanical extracts.
Fuel ethanol factors are weighted average heat contents for undenatured ethanol (3.539 million Btu per barrel) and products used as denaturant (natural gasoline, finished motor gasoline, and motor gasoline blending components--see Tables A1 and A3 for factors).
Lonza's UC-II undenatured type II collagen is supported by multiple clinical studies showing its benefits in relation to joint comfort, mobility, and flexibility from a single daily dose of 40 mg.
Research has shown that a combination of undenatured type-II collagen (UC-II[R]) and tetrahydroiso-alpha acids (ThiAA) help revitalize joint function and performance.
For those seeking natural approaches to combat arthritis, there are natural anti-inflammatory compounds in widespread use today including: undenatured type II collagen, boswellia, and curcumin.
Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein.
The new kid on the block is UCII, a patented undenatured type II collagen from InterHealth.
Exports of Undenatured Ethyl Alcohol of an Alcoholic Strength by Volume of 80% Vol.
Ahmed, "Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein," BMC Immunology, vol.
Bounous and P Gold, "The biological activity of undenatured dietary whey proteins: role of glutathione," Clinical and Investigative Medicine, vol.