Additionally, chromophores such as urocanic
acid, which is formed from L-histidine in the stratum corneum, is a potent endogenous UV-absorbant (56).
4:30 pm: New nature-inspired urocanic
acid mimic preventing DNA damages and immunosuppressive signaling induced by ultraviolet-B radiations--Jean-Francois Nicolay, Exsymol SAM
Further processing is triggered by cysteine protease caspase-14,[sup] which produces the hygroscopic degradation products urocanic
acid and pyrrolidone carboxylic acid (known as essential components of the natural moisturizing factors, NMF).
Based on laboratory investigations, the authors first assumed that the megaloblastic hematopoiesis accompanied by urinary excretion of large amounts of urocanic
acid following oral dose of histidine hydrochloride was responsible for aplastic crisis in these patients with HS.
He recently has focused on a specific skin-barrier protein called filaggrin, which is broken down into a molecule called urocanic
acid the most potent absorber of UVB light in the skin, according to Elias.
When filaggrin deficiency is present, trans urocanic
acid (UCA) does not form.
acid acts as a natural sunscreen of skin of animals and humans.
One such compound is urocanic
acid found on the epidermis layer of human skin and more prevalent when sweating.
Skin: The skin is naturally protected from the sun's radiation by the thickness of the epidermis, melanin, natural antioxidants, DNA repair mechanism, Urocanic
acid and Fas ligand signaling.
A further 8 treatments (humic acid, mannitol, sucrose, root exudates, thiamin, urocanic
acid, cellulose, fulvic acid) showed an increase in the amount of cumulative C[O.
For wavelengths less than 300 nm, epidermal thickness, aromatic amino acids, nucleic acids, urocanic
acid, and melanin are the major factors that influence skin penetration and absorption.
The physical properties of the substances, melanin and urocanic
acid, change with exposure to ultraviolet (UV) light.