Uterine Stimulants

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Uterine Stimulants


a group of medicinal substances that act selectively on the smooth musculature of the uterus and stimulate its contractive capacity.

The action of uterine stimulants varies. Some induce spasms of the musculature, the result of which is vasoconstriction. Others intensify uterine contractions without disrupting their rhythmicity and are used to intensify labor.

Obstetric and gynecological practice makes use of ergot and ergot alkaloid preparations (powder, extract, and ergotal—a mixture of alkaloid phosphates of ergot), ergometrine, methyl ergometrine, and ergotamine, which are used for early postpartal uterine hypotonia and atonia and associated uterine hemorrhage; for hemorrhage after cesarean section or abortion; and for menorrhagia (menstrual hemorrhage). Preparations of the posterior lobe of the pituitary gland (pituitrin and oxytocin) are used to induce and intensify the contractile activity of the uterus during primary or secondary parturient asthenia, for overdue pregnancy, for early postpartal hypotonic hemorrhage, and for normalizing uterine involution after labor or abortion. Certain ganglion blocking agents (pachycarpine, dicolin, dimecolin, spherophysine) increase tonus and intensify uterine contractions; they are prescribed to accelerate labor, especially in women with nephropathy accompanied by hypertension. The uterine stimulants also include extracts, infusions, and tinctures of medicinal plants (shepherd’s purse, the leaves of the common barberry, peppery waterwort) and a number of preparations from various classes of compounds, such as cotarnine chloride (stypticin), Brevicollin, Vincametrin, Isoverin, Vetrazine, and Gravitol. In addition, the group includes agents that do not exert a direct effect on the smooth musculature of the uterus—in particular, those laxatives (castor oil) that induce reflex intensification of uterine contraction by stimulating the receptors of the colon.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Most commonly used medications that contributed to ADRs were hematinics - 42% (ferrous sulfate + iron sucrose), followed by antimicrobials (31%), analgesics (9%), hormones (6%), uterine stimulants (5%), and miscellaneous such as antifibrinolytics (3%), uterine relaxants (2%), mineral (1%), and antihypertensive drugs (1%) [Figure 2].
Figure 2: Spectrum of drugs causing adverse drug reactions Haematinics 42% Antimicrobials 31% Analgesics 9% Hormones 6% Uterine stimulants 5% Miscellaneous 7% Note: Table made from pie chart.
Close monitoring of maternal and fetal response to uterine stimulants is mandatory to avoid complications of obstructed labour and overuse of uterine stimulants.
Patients were assessed in terms of demographics such as age, parity, gestational age, obstetric history, mode of presentation, the use of uterine stimulant, the course of labour, clinical features, type and site of rupture and operative treatment, hospital stay and fetomaternal outcome.