glycoprotein

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glycoprotein

(glī'kōprō`tēn), organic compound composed of both a proteinprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 and a carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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 joined together in covalent chemical linkage. These structures occur in many life forms; they are prevalent and important in mammalian tissues. The attached carbohydrate may have several effects: it may help the protein to fold in the proper geometry, stabilize the protein, affect physical properties such as solubility or viscosity, helps it to orient correctly in a membrane, or make it recognizable to another biochemical or cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). Many proteins released by cells to the blood and other fluids are glycoproteins. One set of glycoproteins also carry the blood groupblood groups,
differentiation of blood by type, classified according to immunological (antigenic) properties, which are determined by specific substances on the surface of red blood cells.
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 determinants. The carbohydrate portion of a glycoprotein is usually a small sugar or no more than 8 to 10 individual monosaccharide units. Combinations of up to seven of the many different sugar molecules known to occur in nature comprise the saccharide portions of mammalian glycoproteins: glucoseglucose,
 dextrose,
or grape sugar,
monosaccharide sugar with the empirical formula C6H12O6 . This carbohydrate occurs in the sap of most plants and in the juice of grapes and other fruits.
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, glucosamine, galactose, galactosamine, mannose, fucose, and sialic acid (a derivative of glucosamine). The linkage between the oligosaccharide and the protein occurs by formation of a chemical bond to only one of four protein amino acids: asparagineasparagine
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of mammalian proteins.
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, hydroxylysine, serineserine
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein.
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, or threoninethreonine
, organic compound, one of the 22 α-amino acids commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein.
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. Solutions of glycoproteins usually exhibit high viscosity, an observation explaining the highly viscous character of egg white, which is composed largely of the glycoprotein ovalbumin. Salivary mucus contains the glycoprotein called mucin. Among other glycoproteins, one particularly interesting example is isolated from certain antarctic fishes who survive near-freezing water temperatures as a result of freezing-point depression of their blood serum by a globular glycoprotein. This molecule is a remarkably effective freezing point depressant.

Glycoprotein

A compound in which carbohydrate (sugar) is covalently linked to protein. The carbohydrate may be in the form of monosaccharides, disaccharides, oligosaccharides, or polysaccharides, and is sometimes referred to as glycan. The sugar may be linked to sulfate or phosphate groups. In different glycoproteins, 100–200 glycan units may be present. Therefore, the carbohydrate content of these compounds varies markedly, from 1% (as in the collagens), to 60% (in certain mucins), to >99% (in glycogen). See Collagen, Glycogen

Glycoproteins are ubiquitous in nature, although they are relatively rare in bacteria. They occur in cells, in both soluble and membrane-bound forms, as well as in the intercellular matrix and in extracellular fluids, and include numerous biologically active macromolecules. A number of glycoproteins are produced industrially by genetic engineering techniques for use as drugs; among them are erythropoietin, interferons, colony stimulating factors, and blood-clotting factors. See Genetic engineering

In most glycoproteins, the carbohydrate is linked to the polypeptide backbone by either N- or O-glycosidic bonds. A different kind of bond is found in glycoproteins that are anchored in cell membranes by a special carbohydrate-containing compound, glycosylphosphatidylinositol, which is attached to the C-terminal amino acid of the protein. A single glycoprotein may contain more than one type of carbohydrate-peptide linkage. N-linked units are typically found in plasma glycoproteins, in ovalbumin, in many enzymes (for example, the ribonucleases), and in immunoglobulins. O-linked units are found in mucins; collagens; and proteoglycans (typical constituents of connective tissues), including chondroitin sulfates, dermatan sulfate, and heparin. See Albumin, Carbohydrate, Enzyme, Immunoglobulin, Monosaccharide, Oligosaccharide, Polysaccharide, Protein

Within any organism, all molecules of a particular protein are identical. In contrast, a variety of structurally distinct carbohydrate units are found not only at different attachment sites of a glycoprotein but even at each single attachment site—a phenomenon known as microheterogeneity. For instance, ovalbumin contains one glycosylated amino acid, but over a dozen different oligosaccharides have been identified at that site, even in a preparation isolated from a single egg of a purebred hen.

glycoprotein

[¦glī·kō′prō‚tēn]
(biochemistry)
Any of a class of conjugated proteins containing both carbohydrate and protein units. Also known as glycopeptide.
References in periodicals archive ?
The deal with Compass Group is the right move for VSG and going forward, their partnership will allow us to further our growth strategy and take the business into a new dimension.
The results of the VSG assessment were reviewed with senior management, and there was a noticeable increase in communication regarding the direction the new company would take and the culture it would have.
The VSG controller can be programmed to function in any application.
Each VSG includes an arbitrary waveform generator (ARB) that produces signals for many types of modulation, among them are PSK, QAM, FSK and MSK.
The new PXIe VSG does more tests in less time, which reduces the cost of testing.
2 is a key release of the Avizo product family", says Pascal Doux, VSG Product Director.
6 GHz PXI Express VSG and VSA to rapidly switch through a preprogrammed list of RF settings, including frequency and power level, at deterministic timing intervals.
Established in 2000, VSG claims to be the fastest growing independent company in the UK's manned guarding industry, employing more than 4,000 staff with an annual turnover of around pounds 90 million.
Pc Joe Griffiths, crime and disorder reduction officer at Ystrad Mynach, said: 'Items include a blue Makita drill with initials YHJ and a full Donald Bradman cricket set in a canvas bag with VSG written in ink.
Las pruebas de laboratorios mostraron leucocitosis y VSG aumentada en 4, PCR positiva en los 5 pacientes e hipoalbuminemia.
VSG single-edge inserts feature five geometries and are available in three new carbide grades.
VSG proteins, which are 400 to 500 amino acids in length, are anchored to the parasite's membrane at their carboxy terminus by a glycosyl-phospatidyl-inositol linkage.