Vaccine Therapy

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Vaccine Therapy


a method of treating certain infectious diseases by administering vaccines. Vaccine therapy is based on I. I. Mechnikov’s teaching on phagocytosis. The repeated injection of vaccine (at certain intervals of time, in certain doses, and a certain number of times) lowers the body’s sensitivity to a specific antigen (causative agent) and causes what is called desensitization. It also intensifies the phagocytosis of the specific causative agent and stimulates the metabolic processes. In the primary focus, it increases hyperemia and the permeability of blood vessels. Autovaccines are used for diseases caused by streptococci and staphylococci and for some other diseases. Killed vaccines are ordinarily used for the vaccine therapy of man; they may be injected subcutaneously, intramuscularly, intradermally, or intravenously. (Sometimes the different methods are combined.) The administration of vaccine often elicits a severe systemic reaction—chills, elevated temperature, increased perspiration, and intensification of pain. (The therapeutic effect sets in later.) Vaccine therapy is contraindicated in the second half of pregnancy, active tuberculosis, cardiac diseases in the stage of decompensation, kidney disorders, severe atherosclerosis, hypertension, and some other diseases.

Veterinarians resort to vaccine therapy comparatively rarely; they use vaccine therapy chiefly to treat protracted, chronic, localized infectious diseases, such as brucellosis, tularemia, colibacteriosis, and staphylococcal infections by stimulating antibody formation. Vaccines made from killed microbes, anavaccines, toxoids, antiviruses, ly sates of microbial cells, autovaccines, and bacteriophages are used for vaccine therapy.

References in periodicals archive ?
Prof Judith Swain, Executive Director of SICS said, "This excellent collaborative discovery between SICS and SIgN is a milestone in vaccine therapy for chronic infections.
tella has technology and know-how for the stable culture of high-quality DCs and other cells, and is providing its DC vaccine therapy as well as other technology and know-how for cancer treatment - which are based on technology developed by the Institute of Medical Science of the University of Tokyo - to 18 medical institutions throughout Japan, including national medical institutions and university hospitals.
s (Seattle WA) treatment, called Provenge, extended lives of men with prostate cancer, "suggest that perhaps we're finally getting through the barriers to effective vaccine therapy in cancer treatment," he said.
Because patient benefit from vaccines requires a fully functional immune system, vaccine therapy will not be optimal in patients having had recent chemotherapy, radiation, or multiple regimens of prior therapies," said Dr.
These agents are in large phase III trials--some of them involving 1,000 advanced melanoma patients--as single-agent therapy, in combination with the alkylating agent dacarbazine (DTIC), as adjuvant therapy in patients with stage III or resected stage IV disease, or in conjunction with peptide vaccine therapy.
Vaccine therapy - or immunotherapy - relies on the potential of activating the immune system to destroy cancer cells.
We will continue to initiate programs that support the commercialization of the Hemopurifier(R) as a potential treatment for dengue and other viral threats resistant to drug and vaccine therapy.
Prima and Prana will jointly share in the benefit of any intellectual property produced from the collaboration including milestone payments and royalties that may accrue as a consequence of producing a successful vaccine therapy.
Onyvax Ltd, London, UK, a leading vaccine therapy company, has completed patient recruitment in its Phase IIa clinical trial in prostate cancer.
Also called allergy vaccine therapy, this treatment consists of a series of injections given over time.
These trials will neither define the portion of atherosclerotic CVD caused by infection nor indicate benefits or risks of vaccine therapy.

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