Vaccine Therapy

Also found in: Medical.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Vaccine Therapy


a method of treating certain infectious diseases by administering vaccines. Vaccine therapy is based on I. I. Mechnikov’s teaching on phagocytosis. The repeated injection of vaccine (at certain intervals of time, in certain doses, and a certain number of times) lowers the body’s sensitivity to a specific antigen (causative agent) and causes what is called desensitization. It also intensifies the phagocytosis of the specific causative agent and stimulates the metabolic processes. In the primary focus, it increases hyperemia and the permeability of blood vessels. Autovaccines are used for diseases caused by streptococci and staphylococci and for some other diseases. Killed vaccines are ordinarily used for the vaccine therapy of man; they may be injected subcutaneously, intramuscularly, intradermally, or intravenously. (Sometimes the different methods are combined.) The administration of vaccine often elicits a severe systemic reaction—chills, elevated temperature, increased perspiration, and intensification of pain. (The therapeutic effect sets in later.) Vaccine therapy is contraindicated in the second half of pregnancy, active tuberculosis, cardiac diseases in the stage of decompensation, kidney disorders, severe atherosclerosis, hypertension, and some other diseases.

Veterinarians resort to vaccine therapy comparatively rarely; they use vaccine therapy chiefly to treat protracted, chronic, localized infectious diseases, such as brucellosis, tularemia, colibacteriosis, and staphylococcal infections by stimulating antibody formation. Vaccines made from killed microbes, anavaccines, toxoids, antiviruses, ly sates of microbial cells, autovaccines, and bacteriophages are used for vaccine therapy.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Xu, "L-BLP25 as a peptide vaccine therapy in non-small cell lung cancer: a review," Journal of Thoracic Disease, vol.
Since the vaccine therapy impacts some parameters of the system, mixed vaccine therapy and chemotherapy treatments are used.
Auto vaccine therapy: (Gives a complete cure to resistant cases of E.Coli UTI)
Prof Judith Swain, Executive Director of SICS said, "This excellent collaborative discovery between SICS and SIgN is a milestone in vaccine therapy for chronic infections.
These vaccines include Allovectin-7 and OncoVEX, for the treatment of Melanoma, BiovaxId (Idiotype vaccine therapy) for follicular non-Hodgkin lymphoma, and GV1001 for advanced pancreatic cancer.
While agreeing in principle with the Phase III study design, the FDA provided a detailed list of issues and items they would like included in the final Phase III study design primarily related to the patient trial population who are low HER2 expressors (the category of breast cancer patients for whom no other vaccine therapy currently exists).
The joint effort aims to enable the culture of cells of higher, more stable quality in a shorter time and at reduced cost, by applying the experience and know-how in medical devices as well as cell processing technology of Asahi Kasei to the immunocyte culture process for dendritic cell (DC) vaccine therapy and other cancer treatment technology under R&D by tella.
angiogenesis inhibitors in lung cancer, vaccine therapy, small cell carcinoma of the lung, mesothelioma, statistical and study design methodologies in clinical oncology research, palliative care for patients with lung cancer, and the future of lung cancer.
Eight patients in the dendritic cell vaccine study experienced remarkable long-term, progression-free survival after completing the vaccine therapy, even though they had widely metastatic disease and/or repeated appearance of new metastases despite various therapies.
The study, along with an April 29 report that Dendreon Inc.'s (Seattle WA) treatment, called Provenge, extended lives of men with prostate cancer, "suggest that perhaps we're finally getting through the barriers to effective vaccine therapy in cancer treatment," he said.
Terando AM, Faries MB, Morton DL Vaccine therapy for melanoma: current status and future directions.
"Because patient benefit from vaccines requires a fully functional immune system, vaccine therapy will not be optimal in patients having had recent chemotherapy, radiation, or multiple regimens of prior therapies," said Dr.

Full browser ?