Vaccine Therapy

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Vaccine Therapy


a method of treating certain infectious diseases by administering vaccines. Vaccine therapy is based on I. I. Mechnikov’s teaching on phagocytosis. The repeated injection of vaccine (at certain intervals of time, in certain doses, and a certain number of times) lowers the body’s sensitivity to a specific antigen (causative agent) and causes what is called desensitization. It also intensifies the phagocytosis of the specific causative agent and stimulates the metabolic processes. In the primary focus, it increases hyperemia and the permeability of blood vessels. Autovaccines are used for diseases caused by streptococci and staphylococci and for some other diseases. Killed vaccines are ordinarily used for the vaccine therapy of man; they may be injected subcutaneously, intramuscularly, intradermally, or intravenously. (Sometimes the different methods are combined.) The administration of vaccine often elicits a severe systemic reaction—chills, elevated temperature, increased perspiration, and intensification of pain. (The therapeutic effect sets in later.) Vaccine therapy is contraindicated in the second half of pregnancy, active tuberculosis, cardiac diseases in the stage of decompensation, kidney disorders, severe atherosclerosis, hypertension, and some other diseases.

Veterinarians resort to vaccine therapy comparatively rarely; they use vaccine therapy chiefly to treat protracted, chronic, localized infectious diseases, such as brucellosis, tularemia, colibacteriosis, and staphylococcal infections by stimulating antibody formation. Vaccines made from killed microbes, anavaccines, toxoids, antiviruses, ly sates of microbial cells, autovaccines, and bacteriophages are used for vaccine therapy.

References in periodicals archive ?
AVAX's core technology platform, termed, Autologous Cell ("AC") Vaccine Technology is a universal platform approach to individualized cancer vaccine therapy.
This SME-led collaboration of two universities with exceptional expertise in vaccinology and immunotherapy, two SMEs with expertise in viral vectored prime-boost immunisation and antigen discovery, and a global pharmaceutical company, will provide complementary abilities to accelerate development of this promising vaccine therapy.
This also means that many of the complex issues associated with current vaccine therapy against chronic infections can be overcome, such as that of genetic diversity of viruses.
While agreeing in principle with the Phase III study design, the FDA provided a detailed list of issues and items they would like included in the final Phase III study design primarily related to the patient trial population who are low HER2 expressors (the category of breast cancer patients for whom no other vaccine therapy currently exists).
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He criticized the way vaccine therapy was being used to treat patients with asthma and warned that these can be dangerous, as such cannot be routinely recommended.
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Eight patients in the dendritic cell vaccine study experienced remarkable long-term, progression-free survival after completing the vaccine therapy, even though they had widely metastatic disease and/or repeated appearance of new metastases despite various therapies.
s (Seattle WA) treatment, called Provenge, extended lives of men with prostate cancer, "suggest that perhaps we're finally getting through the barriers to effective vaccine therapy in cancer treatment," he said.
The patient groups receiving vaccine therapy had improvements in overall survival versus what was predicted, by approximately 6 and 9 months.
Because patient benefit from vaccines requires a fully functional immune system, vaccine therapy will not be optimal in patients having had recent chemotherapy, radiation, or multiple regimens of prior therapies," said Dr.
Vaccine therapy - or immunotherapy - relies on the potential of activating the immune system to destroy cancer cells.

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