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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Estradiol is also available as an inserted vaginal ring (Estring), for treating those conditions as well as urethritis, and in vaginal tablet form (Vagifem).
DR, SIMON When you want the lowest dose of vaginal estradiol, consider Vagifem; the total dose of estrogen is lower over 90 days than with the vaginal ring.
23 August 2010 - Novo Nordisk Inc, part of Danish Novo Nordisk A/S (CPH: NOVO B), said today it has inked an exclusive agreement with Upsher-Smith Laboratories Inc to market Vagifem (estradiol vaginal tablets) 10 mcg.
Vaginal estrogen is available as a cream (Premarin, Estrace), a tablet (Vagifem) and a flexible plastic ring (Estring).
The tablet (Vagifem) is designed for insertion into the vagina via a ready-to-use applicator, so the estrogen is delivered directly to the vagina with minimal absorption elsewhere in the body.
2 December 2009 - Denmark-based healthcare company Novo Nordisk A/S (NYSE: NVO) said today that the US Food and Drug Administration (FDA) has approved a 10 mcg dose formulation of Vagifem (estradiol vaginal tablets) for the treatment of atrophic vaginitis due to menopause.
Described as the first generic equivalent for Vagifem in the market, Yuvafem delivers the same low dose of vaginal estrogen in a preloaded, single-use, disposable applicator.
A program of intravaginal estrogen (Vagifem) 2 to 3 times per week, introital cutaneous lysate (Neogyn) vulvar soothing cream twice per day, and compounded muscle-relaxing intravaginal diazepam suppositories 2 to 3 times per week was initiated.