This technology is well suited for epitope mapping viral envelope proteins
, which usually form complex oligomeric structures and contain post-translational modifications that require expression within mammalian cells to retain their native conformation.
His work on the structure of viral envelope proteins
, particularly in HIV, has resulted in a new class of compounds that block HIV infection in culture.
The objective of a prophylactic HIV vaccine is to provoke the immune system to produce antibodies that target viral envelope proteins
and thereby inactivate the virus, or to induce an immune response that targets cells already infected with virus.