Viral inclusion bodies

Viral inclusion bodies

Abnormal structures which appear within the cell nucleus, the cytoplasm, or both, during the course of virus multiplication. In general, the inclusion bodies are concerned with the developmental processes of the virus. In some virus infections, such as molluscum contagiosum, inclusion bodies may be simply masses of maturing virus particles. In other infections (herpes simplex), typical inclusion bodies do not appear until after the virus has multiplied. Such inclusions may be remnants of the process of virus multiplication.

The presence of inclusion bodies is often important in diagnosis. A cytoplasmic inclusion in nerve cells, the Negri body, is pathogenic for rabies. See Rabies, Virus

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In patients who are severely immunocompromised, viral inclusion bodies may be extremely abundant and demonstrate atypical features (Figure 1, c through f).
Although characteristic viral inclusion bodies in GI biopsies often may be focal and require several histologic levels for identification, their detection in significantly immunocompromised HIV patients is usually not difficult.
Comparison of the 3 Most-Common Viral Inclusion Bodies Seen in Human Immunodeficiency Virus-Associated Gastrointestinal Opportunistic Infections Cytomegalovirus Herpes Simplex Virus Cell type Endothelium, stromal, Epithelium (squamous, epithelium (glandular), less often glandular) macrophage Nucleus Nucleomegaly, eosinophilic Syncytial change, inclusion with surrounding homogenous eosinophilic halo/"owl-eye" "ground-glass" or Cowdry type-A inclusion Cytoplasm Cytomegaly, granular No inclusion basophilic inclusion bodies Adenovirus Cell type Epithelium (surface columnar, goblet cell) Nucleus Nucleomegaly, basophilic "smudged" inclusion Cytoplasm No inclusion
Edema, syncytial cells, viral inclusion bodies, and alveolitis were seen in lung sections.
Even with a biopsy, the viral inclusion bodies can be missed10 and specific staining for CMV may not be carried out when an alternative pathology has been identified.
Liver biopsy shows hepatocytes with the classic viral inclusion bodies of herpes simplex virus.
Immunoelectron microscopy with colloidal gold-labeled antibodies against NS3 protein and the viral nucleocapsid protein revealed in situ accumulation of NS3 protein in the cytoplasm but not in the viral inclusion bodies, vacuoles or chloroplasts of RHBV-infected plants, following the same pattern of distribution as the RHBV nucleocapsid protein.
4b and 4c), especially in collapsing cells that has already accumulated large masses of viral inclusion bodies.
These structures are similar to viral inclusion bodies produced during orbivirus infections (15).