Orotic Acid

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orotic acid

[ə′räd·ik ′as·əd]
C4H4O4N2 A crystalline acid which is a growth factor for certain bacteria and is also a pyrimidine precursor.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Orotic Acid


(also 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid or uracil-6-carboxylic acid), colorless crystals that are poorly soluble in water and organic solvents; melting point, 323°-345°C (with decomposition). Orotic acid was first extracted from cow’s milk in 1905 and later discovered in the milk of other animals and humans. Concentrated mainly in yeasts and in the liver, it is synthesized from aspartic acid and takes part in the biosynthesis of pyrimidine nucleotides, including uridine-5’-monophosphate and cytidine monophosphates. It also stimulates growth in plants and animals. The potassium salt of orotic acid is used in medicine to treat disorders in protein metabolism.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.