Werner's syndrome

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Related to Werner syndrome: progeria, ataxia telangiectasia

Werner's syndrome

[′ver·nərz ‚sin‚drōm]
(medicine)
A complex of symptoms, thought to be inherited as an autosomal recessive, including premature senescence, dwarfism, cataracts, scleroderma-like changes of the skin, osteoporosis, and multiglandular dysfunction.
References in periodicals archive ?
Furuichi, "Werner syndrome: a changing pattern of clinical manifestations In Japan (1917-2008)," BioScience Trends, vol.
Monnat Jr., "Spectrum and risk ofneoplasia in werner syndrome: a systematic review," PLoS ONE, vol.
To do this, they created a cellular model of Werner syndrome by using a cutting-edge gene-editing technology to delete WRN gene in human stem cells.
Werner syndrome. (online) 2010 available from http://www.emed.com /derm .
Mutator phenotype of Werner syndrome is characterised by excessive deletions.
These premature aging syndromes are characterized in progeria by growth retardation and accelerated degenerative changes of the cutaneous, musculoskeletal, and cardiovascular systems in young patients [25], and in Werner syndrome, for which recently the a candidate gene has been identified [26], by an early-onset and accelerated rate of development of major geriatric disorders such as atherosclerosis, diabetes mellitus, osteoporosis, and various neoplasms [27].
Excess of rare cancers in Werner syndrome (adult progeria).
People with the rare genetic disease Werner syndrome appear to age at up to five times the normal rate.
Martin of the University of Washington in Seattle and his colleagues announced that they had found the mutant gene responsible for Werner syndrome (SN: 5/11/96, p.
People born with Werner syndrome start the decline to old age in their twenties.