Primary
Whipple disease of the brain: case report with long-term clinical and MRI follow-up.
Hoppe et al., "Rheumatic and musculoskeletal features of
Whipple disease: a report of 29 cases," Journal of Rheumatology, vol.
Other hepatic bacterial infections that may cause granulomas include
Whipple disease (Tropheryma whippelii), (32) "typhoid nodules" (Salmonella), syphilis, Chlamydia infection, R equi infection, with a granulomatous inflammatory pattern that mimics that of M avium-intracellulare; and melioidosis (Pseudomonas pseudomallei), with either small neutrophilic microabscesses or granulomas.
Godeau, "
Whipple disease. Clinical review of 52 cases.
We prescribed treatment for these patients, including 1 who had been taking lifelong prophylactic doxycycline, as reported for a patient with classic
Whipple disease (25).
(60,61)
Whipple disease, infection by Tropheryma whippelii, almost always involves the small intestine and mesenteric lymph nodes and causes pericarditis in 75%, endocarditis in 50%, myocardial fibrosis in 10%, and myocarditis in 1% of cases.
Thus, a change in genotype in a patient with
Whipple disease must be interpreted as an infection with a different strain and cannot be attributed to mutation of the original strain.
Other cases of solitary CNS
Whipple disease have also involved the frontoparietal regions, and in one of these, there was associated destruction of the calvarium adjacent to the lesion.
The morphologic differential diagnosis included Mycobacterium species,
Whipple disease, and granular cell tumor.
Whipple disease, a rare sporadic disease, was first considered a metabolic disease (1) and later suspected to be an infectious disease caused by a rare bacterium, Tropheryma whipplei (2).
Tropheryma whipplei is a bacterium widely known to be associated with
Whipple disease (WD), which is characterized by various clinical signs such as diarrhea, weight loss, lymphadenopathy, and polyarthritis (1).
Tropheryma whipplei is known mainly as the bacterial pathogen responsible for
Whipple disease (1).
