mutant

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mutant

an animal, organism, or gene that has undergone mutation

Mutant

 

a hereditarily altered form of an organism that differs from the original type in some abnormality that arose through mutation.

Organisms with hereditary changes that appear suddenly have been known for several hundreds of years. For example, at the end of the 18th century a mutant form of sheep with short legs appeared. It later became the first of the Ancona breed. After the discovery of artificial mutagenesis in the 1920’s and 1930’s, numerous mutants of microorganisms, plants, and animals were obtained and used both for actual breeding purposes and for experiments designed to determine patterns in the mutation process. Both the biochemistry of genetics and many metabolic processes were elucidated by means of biochemical mutants that had lost the capacity of the original, wild type microorganism to synthesize essential compounds, such as vitamins, amino acids, and nitrogenous bases.

S. M. GERSHENZON

mutant

[′myüt·ənt]
(genetics)
An individual bearing an allele that has undergone mutation and is expressed in the phenotype.

mutant

(programming)
Microsoft's term for a mutex which is generally used in user mode but can also be used in kernel mode. According to this terminology a mutex is only used in kernel mode.

["Microsoft Windows NT Workstation Resource Kit"].
References in periodicals archive ?
To examine whether the spike mutations affect sensitivity to the neutralizing activity of antibodies against wild-type spike, we investigated whether the antibodies generated in mice immunized with wild-type spike antigen are able to neutralize the spike mutant viruses as efficiently as wild-type virus. We performed a 50% pseudoparticle neutralization test assay on wild-type and mutant spike-pseudotyped lentiviruses and then compared their neutralizing efficacy.
Thus, in this study we generated and evaluated in a mouse model a pair of H1N1 LAIVs containing NP either from MDV (6: 2 LAIV) or from wild-type virus (5: 3 LAIV).
The RT PR sequences obtained from the patient are compared to the RTPR sequences of the wild-type virus and examined for mutations at resistance sites.
Herpes zoster associated with the Oka vaccine strain has been documented in 23 vaccinees; another 15 turned out to have wild-type virus.
Apparently he too had reverted to the wild-type virus: His T cells are now back up over 200, and his viral load is a manageable 400.
Infectious virus may be identified in the feces as early as 4 days after the intravenous injection of infectious material in susceptible primates (7 days in animals fed wild-type virus orally), and continues to increase in magnitude until just before the onset of chemical evidence of liver disease.
Wild-type virus UDL-01/08 was compared to UDL-01/08 HA backbone variants with A180T and A180V substitutions, and wild-type virus SKP-827/16 was compared with SKP-827/16 HA backbone variants with T180A and T180V substitutions.
We found that when the new vaccine, containing gene sequences similar to the wild-type virus, was used in vaccination studies, the vaccinated birds were protected from disease and shed less of the wild-type virus after challenge," says Yu.
The wild-type virus is found in the natural infection, in contrast to the virus strain found in vaccine.
In addition, the vaccine strain may reactivate, causing a zoster-like illness similar to that caused by reactivation of the wild-type virus [7].
Virological failures were 11 (7%) versus 5 (3%) with evidence of one case of wild-type virus in both arms and one subject with an emergent PI resistance at failure (10I/V, 48V, 54V, 82A, 84V) in the SQV/r arm.
The risk could take the form of either wild-type virus escaping from a facility or vaccine-derived polioviruses.