Williamson Synthesis

Williamson synthesis

[′wil·yəm·sən ′sin·thə·səs]
(organic chemistry)
The synthesis of ethers utilizing an alkyl iodide and sodium alcoholate.

Williamson Synthesis


in organic chemistry, one of the methods of preparing ethers from alkoxides or phenoxides of alkali metals and alkyl halides:

R - X + Me - OR′→R - O - R→ + MeX

where R is an alkyl, R′ is an alkyl or aryl, Me is an atom of an alkali metal, and X is a halogen atom.

The method was developed by the British chemist A. W. Williamson (1824-1904). Dialkyl sulfates, (RO)2SO2, may be used in place of alkyl halides. Reactions analogous to the Williamson synthesis are used in preparing esters and acid anhydrides.

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References in periodicals archive ?
Claisen condensation, Diels-Alder, Grignard, Hoffman rearrangement, Robinson-Schopf, Schotten-Bauman, Swern's oxidation, Ullman Ether synthesis, Williamson synthesis .

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