Politano, "Determining the role of skewed X-chromosome
inactivation in developing muscle symptoms in carriers of Duchenne muscular dystrophy," Human Genetics, vol.
In Caenorhabditis elegans sex-1 is located on the X-chromosome
, and it has been confirmed to be a key gene in the negative regulation of transcription of xol-1 (see http://www.wormbase.org/species/c_elegans/gene/WBGene00004786#0-9g-3).
Recording of sex chromatin has gained importance in human genetics for establishing the relationship with X-chromosome
and determination of the sex of individual has great medico-legal importance to solve many criminal and civil problems.
Another possibility is that these embryos could represent the XX male genotype, in which a portion of the Y-chromosome translocated to the X-chromosome
Grafodatskaya et al., "Isolation of MECP2-null Rett syndrome patient hiPS cells and isogenic controls through X-chromosome
inactivation," Human Molecular Genetics, vol.
Female mammals are subject to further silencing activity--one of their two X-chromosomes
is silenced during embryonic development.
Adrenal myelolipomas show nonrandom X-chromosome
inactivation in hematopoietic elements and fat: support for a clonal origin of myelolipomas.
lncRNAs play a critical role in several important cellular processes, such as the regulation of imprinting and X-chromosome
Gene action in the X-chromosome
of the mouse (Mus musculus L.).
X chromosome aneuploidy: 45 XO or variant of X-chromosome
Several causes such as skewed X-chromosome
inactivation, genomic imprinting, single gene mutations, chromosomal instability and sperm chromosomal abnormalities have been suggested to explain the reproductive losses (13).
Some further support for the notion that PLAC1 is a key element in normal placental development and maintenance comes from the location of the PLAC1 gene in a region of the X-chromosome
near HPRT, a region in which deletions are known to result in placental abnormalities .