XIST


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XIST

(genetics)
The X-linked gene whose RNA transcript mediates X-chromosome inactivation in mammals.
References in periodicals archive ?
Rastan, "Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation," Cell, vol.
The study suggests that over-production of XIST and genes from the inactive X chromosome are common denominators in the development of psychiatric disorders in patients with rare chromosome disorders, such as Klinefelter syndrome and Triple X syndrome, and in the general population of female psychiatric patients.
[4] Nonstandard abbreviations: AKI, acute kidney injury; ICU, intensive care unit; RRT, renal replacement therapy; ncRNA, noncoding RNA; lncRNA, long ncRNA; AMI, acute myocardial infarction; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; CRP, C-reactive protein; SOFA, sequential organ failure assessment; APACHE II, Acute Physiology and Chronic Health Evaluation II; RIFLE, risk, injury, failure, loss of kidney function, and end-stage kidney disease; cel-miR-39, Caenorhabditis elegans microRNA 39; microRNA; AACt, threshold cycle; TapSAKI, TrAnscript Predicting Survival in AKI; AUC, area under the ROC curve; Xist, X-inactlve specific transcript.
From genes that are downregulated in female and upregulated in male sfx mice, we found 13 genes (Akt2, Sdc4, Myf6, Pabpn1, Itgb5, Tnnt2, MAP1, Pfn1, Tsix, Xist, Srebf1, Arf5, and Hdgf) that are connected to collagen synthesis.
This mechanism of action has been described for the well-known regulator of imprinting Xist that remains tethered to its site of transcription [13] and for HOTAIR that instead acts in trans [14].
Cerevisiae) HNRNPA2B1 -2.9 3181 Heterogeneous nuclear ribonucleoprotein A2/B1 XIST -2.8 7503 X (inactive)-specific transcript (non-protein coding) SNORA33 -2.6 594839 Small nucleolar RNA, H/ACA box 33 SNHG12 -2.5 85028 Small nucleolar RNA host gene 12 (non-protein coding) C20orf197 -2.4 284756 Chromosome 20 open reading frame 197 EML2 -2.4 24139 Echinoderm microtubule associated protein like 2 PNISR -2.3 25957 PNN-interacting serine/ arginine-rich protein KIAA0020 -2.3 9933 Kiaa0020 HMMR -2.2 3161 Hyaluronan-mediated motility receptor (RHAMM) NOP58 -2.2 51602 NOP58 ribonucleoprotein homolog (yeast) PILRB -2 29990 Paired immunoglobin-like type 2 receptor beta NCAPG -2 64151 Non-SMC condensin I complex, subunit G PICALM -2 8301 Phosphatidylinositol binding clathrin assembly protein
This is driven by the X-inactivation gene (XIST), which produces a noncoding RNA that covers the entire X chromosome and essentially silences it--making it inactive and condensing it into what is termed a Barr body.
Brenda Ponnay (author); SECRET AGENT JOSEPHINE IN PARIS; Xist Publishing (Children's: Picture Books) 18.99 ISBN: 9781623955243
Cells do that using a chunk of RNA called XIST, which is made by one X chromosome but not the other.
They did it by harnessing a naturally-occurring chromosome "off-switch", the XIST gene.
Elan Corporation, plc is a neuroscience-focused biotechnology company, that brings innovations in science to fill significant unmet medical needs that continue to xist around the world.