Effect of Silymarin extract administration and g-irradiation exposure on the activities of serum enzymes (ALT, AST, ALP and GGT), hepatic MDA and xanthine oxidoreductase
system (XO and XDH) and hepatic GSH and the activities of SOD and CAT.
(XOR) is part of a group of enzymes known as the molybdenum iron-sulfur flavin hydroxylases; it is an evolutionarily conserved housekeeping enzyme, with a principal role in purine catabolism by catalyzing the two last steps in purine catabolism, forming uric acid from hypoxanthine and xanthine.
The enzyme xanthine oxidoreductase
(XOR) has a wide distribution throughout living organisms and is highly conserved in prokaryotic, plant, and animal species (reviewed in ).
(XOR) is a rate-limiting enzyme of the purine degradation pathway, oxidizing hypoxanthine into xanthine and xanthine into uric acid.
Both xanthine oxidase and xanthine dehydrogenase, collectively called xanthine oxidoreductase
, is known as the rate-limiting enzyme in purine and pyrimidine catabolism.
Purification, characterisation and kinetic study on the milk molybdoflavoenzyme, xanthine oxidoreductase
, from different species.
The two major systems generating vascular oxidative stress are the NADPH oxidase and xanthine oxidoreductase
From the Cover: Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase
inhibition of cardiac excitation-contraction coupling.
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Simultaneous treatment with citrate prevents nephropathy induced by FYX-051, a xanthine oxidoreductase
inhibitor, in rats.
An extremely potent inhibitor of xanthine oxidoreductase
The results revealed that administration of adenosine before irradiation induced significant protection to the parameters of oxidative stress, amelioration of xanthine oxidoreductase
(XOR) system and uric acid, besides significant improvement of markers of heart damage.