xenobiotic

(redirected from Xenobiotics)
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xenobiotic

[‚zēn·ə·bī′äd·ik]
(biochemistry)
A chemical that is not normally found in the body, such as a drug.
References in periodicals archive ?
With respect to metabolism of xenobiotics, it is not just metabolism to electrophilic species or so-called phase I metabolism resulting in toxicity, but also detoxification genes or so-called phase II metabolism that can be expected to yield important modulating polymorphisms.
Additionally, in this work Roundup presents a differential time effect at nontoxic levels on aromatase activity of JEG3 cells; this phenomenon was already observed with other xenobiotics such as lindane and bisphenol A (Nativelle-Serpentini et al.
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and xenobiotics.
Because SXR/PXR exhibits species-specific differences in its response to phytoestrogens, clinically important drugs, and xenobiotics (Blumberg et al.
An additional source of vulnerability in fetuses and young children is that the blood-brain barrier is not fully developed, and therefore xenobiotics may be more easily able to enter the central nervous system (Rodier 1995).
One of the results of phasing out persistent organic pollutants is that more xenobiotics now have shorter half-lives, and a biological sample taken in late pregnancy or after birth cannot be considered representative of in vivo levels at the time of conception or during early pregnancy (reviewed in MacIntosh et al.
An extensive body of evidence has demonstrated the sensitivity of Fanconi anemia (FA) cells to redox-active xenobiotics, such as mitomycin C, diepoxybutane, cisplatin, and 8-methoxypsoralen plus ultraviolet irradiation, with toxicity mechanisms that are consistent with a deficiency of FA cells in coping with oxidative stress.