Zelinskii-Stadnikov Reaction

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Zelinskii-Stadnikov Reaction

 

a method of synthesizing α-amino acids from aldehydes and ketones. For exampie,

where R and R’ is H, an aliphatic, alicyclic, or aromatic radical. The reaction is run in aqueous mediums at 0°-20°C and takes several hours. Alpha-aminonitriles (I), which are further hydrolyzed to cramino acids (II), are formed with a yield of 60–90 percent. The Zelinskii-Stadnikov reaction is an improved form of the method of cyanohydrin synthesis of α-amino acids developed by the German chemist A. Strecker in 1850. The reaction was discovered by N. D. Zelinskii and G. Stadnikov in 1906.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.