Thorpe reaction

(redirected from Ziegler method)

Thorpe reaction

[′thȯrp rē‚ak·shən]
(organic chemistry)
The reaction by which, in presence of lithium amides, α,ω-dinitriles undergo base-catalyzed condensation to cyclic iminonitriles, which can be hydrolyzed and decarboxylated to cyclic ketones.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.