zinc finger

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zinc finger

[¦ziŋk ¦fiŋ·gər]
(biochemistry)
A small structural domain that is organized around a zinc ion and is found in many gene-regulatory proteins.
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The technology is based on a type of DNA-binding proteins known as zinc fingers.
Notably, the two zinc fingers domains were described to be necessary for GATA3 protein in binding to DNA as well as the stabilization of binding function.
It is also likely that Protein 2 comprises the Gag protein of the virus, which contains zinc fingers (Berg, 1986).
An experimentally tested scenario for the structural evolution of eukaryotic Cys2His2 Zinc Fingers from Eubacterial Ros Homologs.
To artificially confer this invulnerability, June's team removed T cells from 12 HIV-infected patients who were taking standard antiviral drugs and used zinc fingers to delete the doorway receptor gene.
While they represented a great improvement over zinc fingers, however, TALENs are large proteins that are cumbersome to work with and deliver into cells.
The predicted NtCO1 protein contains two B-box-type zinc fingers and a CCT domain.
Zinc fingers are structures that recognize and grab onto a specific sequence of DNA letters.
Recently, structural homology modeling has been performed as to canonical DNA binding of Bcl11b zinc fingers, which is based on the high-resolution crystal structure of the zinc finger domains of the transcription factor Egr1 in complex with DNA.
According to Kraig Biocraft Laboratories Inc, the zinc fingers are an effective genetic engineering technology that it is employing to create the next generation of bio materials, including recombinant spider silks, for the textile and technical textile markets.
Structurally zinc fingers help to stabilize DNA, RNA, proteins and the plasma membrane.
The tricky part is to limit the zinc fingers to the sequence you are interested in to avoid introducing DNA breaks or new mutations elsewhere in the genome.

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