Zollinger-Ellison syndrome


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Related to Zollinger-Ellison syndrome: dyspepsia, carcinoid syndrome

Zollinger-Ellison syndrome

[′zäl·ən·jər ′el·ə·sən ‚sin‚drōm]
(medicine)
Gastric hypersecretion and hyperacidity, fulminating intractable atypical peptic ulceration, and hyperplasia of the islet cells of the pancreas.
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Zollinger-Ellison syndrome and NSAID use are responsible for some cases of peptic ulcer disease, but the vast majority are caused by Helicobacter pylori infection.
Two of the 143 patients developed gastric carcinoids during omeprazole treatment, which is consistent with the 1% historical incidence of this disease in patients with sporadic Zollinger-Ellison syndrome, said Dr.
The illness associated with these tumors is sometimes called Zollinger-Ellison syndrome.
The "Zollinger-Ellison Syndrome Therapy Area Pipeline Report" contains detailed information on the Zollinger-Ellison syndrome drug pipeline.
16-19,24,27,28) Later, a variety of endocrine syndromes including the Zollinger-Ellison syndrome, carcinoid syndrome, multiple endocrine neoplasia type 1 syndrome, and Cushing syndrome were reported in association with ampullary carcinoids.
Patients were excluded if they had coexisting systemic disease affecting the esophagus, active gastrointestinal bleeding, Zollinger-Ellison syndrome, esophageal varices, significant disease of major organs, abnormal laboratory values, current alcohol or illegal drug use, use of a PPI in the previous 3 months, or use of anticholinergic or prokinetic drugs during the screening period.
Also excluded were patients in whom esophagogastroduo-denoscopy could not be completed or a full series of biopsies obtained, as well as those with Zollinger-Ellison syndrome.
Recently, however, researchers have identified very powerful blockers of stomach acid release that have proven effective in controlling most cases of Zollinger-Ellison syndrome.