Prevalence of MS and all of its components increased significantly with increased serum ALT level, whereas
HDLC levels decreased markedly (p< 0.001; Figure 1).
Table 1 Demographic and clinical characteristics of population Controls (n=16 ses) Patients (n=16 ses) (m/f) S/S (m/f) S/S Median Rank Median Rank Age (years) 5S 46-78 66 4S-74
HDLc (mg/dl) 49.5 34-5(5.7 3S.35 34-101.5S HCY([micro]M) 10.275 6.13-15.2 16.635 13.6-20.23 APO Al (mg/dl) 149 70-222 126.5 89-175 PON 1 (U/i) 157.S5 42.55-6S4.S7 1S5.331 73.05-4S3.97 p value Age (years) 0.0700
HDLc (mg/dl) 0.1806 HCY([micro]M) <0.0001 APO Al (mg/dl) 0.3554 PON 1 (U/i) 0.2067 Nota:
HDLc: High-density lipoprotein cholesterol; HCY: Homocysteinc; APOA1: Apolipoprotcin Al; PON1: paraoxonase 1.
Analyses of plasma or serum were done in an accredited laboratory with commercially available enzymatic assays for TG and TC; homogenous immunoassay assays for
HDLC and LDLC (direct) were performed with Synchron series reagent kits using a DXc automated analyser (Beckman Coulter, USA).
Individuals with Metabolic Syndrome: These participants were recruited using International Diabetic Federation (IDF) criteria (abdominal obesity: WC>94 cm and at least two of the following: hypertriglyceridemia (plasma triglycerides> 150 mg/dl), low
HDLC (plasma HDLC<40 mg/dl), high blood pressure (BP) (BP>130/85 mmHg) and high fasting glucose (plasma glucose>100 mg/dl) (29).
Serum total cholesterol, high density lipoprotein cholesterol (
HDLc), cholesterol/HDLc, triglyceride (TG), low density lipoprotein cholesterol (LDLc) and VLDL (TG/5) were evaluated according to the method described by( Junkr, et al., 2008) Statistical analysis: Results were expressed as the mean S.E.
Blood was collected by puncturing the retro-orbital venous plexus, immediately centrifuged (3000 rpm per 10 min), and serum was obtained for biochemical analysis of triglycerides, total cholesterol and its
HDLc, LDLc and VLDLc fractions.
Values for total cholesterol (TC), low-density lipoprotein (LDLC), high-density lipoprotein (
HDLC), and triglycerides (TRIG) were provided for participating children and their parents.
Fasting blood samples were obtained from the participants and were analyzed for serum adiponectin level fasting blood glucose (FBG) glycosylated hemoglobin (HbA1c) triglycerides (TG) total cholesterol (TC) low density lipoprotein cholesterol (LDLC) high density lipoprotein cholesterol (
HDLC) and very low density lipoprotein cholesterol (VLDLC).