Encyclopedia

analgesic

Also found in: Dictionary, Medical, Wikipedia.
(redirected from Nalbuphine)

analgesic

1. of or causing analgesia
2. a substance that produces analgesia
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

analgesic

[‚an·əl′jēz·ik]
(pharmacology)
Any drug, such as salicylates, morphine, or opiates, used primarily for the relief of pain.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Analgesic

 

a medicinal substance that relieves pain. Analgesics are a structurally varied group of medicines. Narcotic analgesics (seeNARCOTIC) are distinguished from nonnarcotic analgesics. The latter group comprises derivatives of salicylic acid, pyrazolone, aniline, and indole; in addition to being analgesics, these derivatives are antipyretics and anti-inflammatories. Amidopyrine, analgin, butadion, phenacetin, acetyl-salicylic acid, and other similar preparations are used for musculoarticulatory pains, neuralgias, headaches, and toothaches, but they are only mildly effective against acute pain caused by traumas or spasms in the smooth musculature.

Analgesics alter the body’s sensitivity to pain by predominantly affecting brain centers and/or the pituitary-adrenal system. Nonnarcotic analgesics, in contrast to narcotic analgesics, anesthetizing remedies, and anesthetics (seeANESTHETIC), do not influence any senses other than touch and do not affect mental functioning or the coughing and respiratory centers. Furthermore, nonnarcotic anesthetics are not somnifacient or addictive. (SeeANTIPYRETICS.)

REFERENCES

Zakusov, V. V. Farmakologiia nervnoi sistemy. Moscow, 1953.
Zakusov, V. V. Farmakologiia. Moscow, 1966.
Mashkovskii, M. D. Lekarstvennye sredstva, part 1. Moscow, 1972.
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
Mentioned in
References in periodicals archive
All study participants receiving postoperative intravenous analgesia (PCIA) are as follows: Group S (sufentanil): 25 (ngffigThml-1) sufentanil plus 1 mg x [ml.sup.-1] flurbiprofen; Group L (low-dose nalbuphine): 15 ([micro]g x [kg.sup.-1] x [ml.sup.-1])nalbuphine plus 1 mg x [ml.sup.-1] flurbiprofen; Group M (medium-dose nalbuphine): 20 ([micro]g x [kg.sup.-1] x [ml.sup.-1]) nalbuphine plus 1 mg x [ml.sup.-1] flurbiprofen; and Group H (high-dose nalbuphine): 25 ([micro]g x [kg.sup.-1] x [ml.sup.-1]) nalbuphine plus 1 mg x [ml.sup.-1] flurbiprofen.
Yoa-Pu Hu, "Controlled release of nalbuphine propionate from biodegradable microspheres: in vitro and in vivo studies," International Journal of Pharmaceutics, vol.
They also received 10 mg of nalbuphine hydrochloride given intravenously 10 minutes before surgery.
The opiates, along with their semi-synthetic opioid derivatives (heroin, hydrocodone, hydromorphone, nalbuphine, oxycodone, oxymorphone) and the increasing number of completely synthetic opioids (propoxyphene, levorphanol, meperidine, diphenoxylate, butorphanol, methadone, fentanyl derivatives, tramadol, buprenorphine, tapentadol) have a long and checkered history in medicine.
Postoperative analgesia was obtained with the use of subcutaneous nalbuphine hydrochloride (2 mg/kg).
In a study (69) similar to the earlier in vitro investigations of Hermens et al (66), solutions of fentanyl, sulfentanil and pethidine as well as morphine, but not alfentanil, nalbuphine and naloxone (all at 5x[10.sup.-4] M), were shown to produce wheal and flare responses after intradermal injection in human volunteers and naloxone attenuated both the wheal and flare to fentanyl and the flare to morphine.
Copyright © 2003-2025 Farlex, Inc Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.