The Tritonia diomedea swim
afferent neurons may use glutamate as their neurotransmitter.
Cardiac
afferent neurons express ASIC3 that are activated by mild acidification during ischemia [132, 133].
Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse
afferent neurons. Neuroscience 2014; 277: 679-89.
[N.sub.inf] represents predominantly A[delta] afferents and C-neurons (slowly conducting fibers that are specified as nociceptors), while [N.sub.0] represents A[alpha]/[beta]
afferent neurons (intermediate conducting fibers associated with mechanoreceptors) (22,24,25).
Nociceptive pain is defined as pain resulting from the on-going activation of primary
afferent neurons by noxious stimuli (McCaffery & Pasero, 1999).
This analgesic function is due to its capability of depleting substance P stores from the primary
afferent neurons, eventually relieving pain in conditions like peripheral arthritis.
Hyperpolarizing potentials have been described in the squid stellate ganglion (Miledi, 1972), in secondary hair cells and
afferent neurons of the squid statocyst (Williamson, 1989), and in central neurons of the cuttlefish (Chrachri and Williamson, 2003).
Furthermore, several studies have shown that the arbours of small-diameter primary C-fibre afferents can enlarge greatly in rats and mice after SCI potentially leading to increased reflex excitation of preganglionic neurons, via interneuronal pathways.[sup.15] These
afferent neurons are CGRP-immunoreactive, and are believed to mediate the spinal reflex pathways to the sympathetic preganglionic neurons, and hence play a significant role in the pathogenesis of NDO.[sup.11,15]
Descending spinal noradrenergic and serotonergic neurons inhibit the neurotransmitters noradrenaline and serotonin, released from primary
afferent neurons and dorsal horn neurons.
Receptor localization in the mammalian dorsal horn and primary
afferent neurons. Brain Research, Brain Research Reviews, 24(1), 28-66.
In addition,
afferent neurons may synapse with other afferent nerve cells within the central nervous system.