(1985) Isolation and characterization of
thromboxane synthase from human platelets as a cytochrome P-450 enzyme.
Effect of onion and ginger consumption on platelet
thromboxane production in humans.
Abe, "Rat kidney
thromboxane receptor: Molecular cloning, signal transduction, and intrarenal expression localization," Journal of Clinical Investigation, vol.
These larger platelets secrete more serotonin, b-thromboglobulin and
thromboxane A2 as compared to comparatively smaller platelets13-16.
Oh-ishi, Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over
thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages, Biochemical and Biophysical Research Communication, 230(1), 110-114 (1997).
It occurs as a result of cold-induced cell death and development of localized inflammatory processes and tissue ischemia mediated by
thromboxane A2, prostaglandin F2-alpha, bradykinins, and histamine (1).
One proposal was the prescription of acetylsalicylic acid in low doses (75-100 mg/day) to reduce inflammation and improve the balance between
thromboxane A2/ prostacyclin.
Biomarkers analysed from both urine and plasma samples included cortisol (also analysed from saliva), substance P (SUBP), leukotriene B4 (LTB4),
thromboxane B2 (Tbx-B2) and midkine.
In contrast to the traditional notion of "resistance" as an inherent or acquired defense or chemical blockage of a drug, whether by a microbe or the host, aspirin resistance may be either a laboratory-defined lack of inhibition of
thromboxane A2, or a clinically defined entity.