loss of heterozygosity
loss of heterozygosity
[¦lȯs əv ‚hed·e·rō·zī′gäs·əd·ē] (genetics)
In a heterozygote, the loss of one of the two alleles at one or more loci in a cell lineage or cancer cell population due to chromosome loss, deletion, or mitotic crossing-over. Abbreviated LOH.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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