abasia

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abasia

[ā′bā·zhə]
(medicine)
Lack of muscular coordination in walking.
References in periodicals archive ?
The aldehyde residue of abasic sites can generate an interstrand crosslink by reacting with the exocyclic amino group of a guanine base (34).
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions.
Both providers remain strong cash flow generators, despite the recession thanks to their massive retail subscriber bases, the abasic need' nature of mobile voice service, sound cost control and reasonable investment policies.
An Isa, or Individual Savings Account, should be your first choice for any spare cash if you're abasic or higher rate taxpayer.
SSB Endo III sites, reflecting abasic sites and oxopyrimidines, were evaluated by a modified version of comet assay with Endo III treatment (Collins et al.
In addition, destabilization of the sense strand through other modifications such as non-canonical bases, mismatches, and abasic sites at strategic regions also played a role in improving siRNA potency in vitro.
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites," The EMBO Journal, vol.
Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is the major mammalian abasic endonuclease and initiates repair of this cytotoxic/mutagenic lesion by incising the DNA backbone via a [Mg.
Radicella, "XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions," The EMBO Journal, vol.
UDG hydrolyses the N-glycosidic bond between the uracil base and the sugar phosphate backbone, thus generating abasic sites on the DNA strand at which certain DNA polymerases are likely to halt (14).
Inhibition of AP endonuclease by lucanthone leads to the accumulation of abasic sites in DNA that are converted to lethal double-strand breaks leading to sensitization of tumor cells to alkylating agents and to radiation.