Absolute Configuration of the Secondary Alcohol in 1 and 5 [17, 18].
My way since 1973 to circumvent these difficulties has been through enantioselective synthesis of the target pheromone itself by starting from a compound of known
absolute configuration. If chiroptical properties or enantioselective gas chromatographic (GC) behavior of the natural pheromone is recorded, then these data can be compared with the corresponding data of the synthetic material.
Kita, "'H NMR determination of
absolute configuration of 1- or 2-arylsubstituted alcohols and amines by means of their diastereomers: novel separation technique of diastereomeric derivatives of pyridyl alcohols by extraction," Chemistry, vol.
Circular dichroism, a powerfull tool for the assessment of
absolute configuration of flavonoids.
Absolute configuration and enantiomer composition of hormosirene.
SMART again can be of assistance, as it is capable of determining
absolute configurations.
The
absolute configuration of 2 was proposed as shown by analogy to 8, which was also supported by the nearly identical specific rotation values recorded for both compounds [17].
In addition, they can be used to predict the
absolute configuration of the chiral center in many instances.
Synthesis and determination of the
absolute configurationTheir focus is on the principles that govern relative and
absolute configurations in transition state assemblies.
The next five chapters discuss separations, offering treatments of resolution of chiral drugs and drug intermediates by crystallization, isolation and production of optically pure drugs by enantioselective (able to select one of a chiral pair) chromatography, stereoselective chromatographic methods for drug analysis, capillary electrophoresis coupled to mass spectrometry for chiral drugs analysis, and chiral molecular tools for preparation of enantiopure alcohols and simultaneous determination of their
absolute configurations by x-ray crystallography or anisotrophy methods.
He also developed convenient method for the determination of
absolute configurations of chiral carboxylic acids, a-amino acids, amino alcohols, polynucleic acids and ephedrine isomers by partially or totally restricting their conformational flexibility through complexation with trinuclear metals, such as Fe, Cr, Mn, Rh, Ru, etc., L A1/4 water or pyridine and n A1/4 0 or 1.