Epidermolytic acanthoma can present as solitary or multiple (disseminated) lesions on the trunk, extremities, or genitalia.
The histopathologic features of epidermolytic acanthoma frequently raise suspicion for condyloma acuminatum or VV to the untrained eye.
There are more than 20 lesions in the literature described for an eruptive-type acanthoma with diameters ranging from 1 to 10 mm and mostly localized to the leg.
Epidermal tumor with an unusual appearance: Clear cell acanthoma. Ann Dermatol Syphiligr (Paris) 1962;89:361-71.
One case with the classical morphology but with additional apocrine differentiation was considered a distinct entity, reported as reticulated acanthoma with apocrine differentiation (15).
Initially reported as superficial epithelioma due to its unknown histogenesis and biological behavior, the term has remained unchanged by some authors and has been criticized by others, who have proposed replacing the name with reticulated acanthoma (13).
The clinical differential diagnosis for trichofolliculoma includes dermal nevus, basal cell carcinoma, and pilar sheath acanthoma. These cutaneous entities may be ruled out by histopathology.
The histopathology of pilar sheath acanthoma shows dermal proliferation of lobules comprising benign squamous epithelium that arrange themselves around small cystic spaces.
The benign tumors are: Trichofolliculoma, Pilar sheath acanthoma
, Fibrofolliculoma, Trichodiscoma, Trichoepithelioma, Trichoblastoma, Trichoadenoma, Pilomartricoma, Trichilemmoma, Trichilemmal horn and Proliferating trichilemmal cyst.
Keratotic lesions that are "flat" histologically, with minimal epidermal thickening and no downward budding, can usefully be signed out as "seborrheic keratosis, flat type," "solar lentigo, flat type" (usually on sun-damaged skin of head and neck), (3) or "large cell acanthoma
" if the lesional keratinocytes are clearly markedly increased in size (Figure 1, B).
Acantholytic dyskeratotic acanthoma
: a variant of a benign keratosis.
Soft tissue tumors constituted the largest group 61.2 %, followed by appendageal tumors 22.0 %, melanocytic tumors (Naevi) 12.3 % and keratinocytic tumors (verruca, papilloma, acanthomas