nigricans and endometrioid adenocarcinoma of the parametrium: The search for malignancy.
Approximately 53% had documented insulin resistance, 48% presented acanthosis
nigricans, and 13% of the female patients had polycystic ovarian syndrome.
The commonest histopathological features recognized in our study were sawtooth rete ridges/ irregular acanthosis
in 85%, vacuolar degeneration of basal layer in 81.7%, band-like infiltrate in 71.7%, hyperkeratosis/ orthokeratosis in 63.3% and wedge-shaped hypergranulosis in 61.7% of cases (Figure 2).
AIC applied in both directions (i.e., forward and backward selection), provided a final model comprised of eight characteristics: gender, age, family history of DM2, DBP, SBP, acanthosis
nigricans, BMI, and height, with a final AIC of 298.25 (Table 2).
nigricans of the neck, axillae, the external genitalia and antecubital regions, generalized lanugo, mildly decreased subcutaneous fat, coarse face, large ears, high nasal bridge, upturned nose, abnormalities of the teeth, gingival hyperplasia, and polydactyly in her left hand were noted (Figure 1).
CARP is poorly recognized by clinicians and frequently initially misdiagnosed because of its similar appearance to other disorders, most commonly tinea versicolor and acanthosis
From these observations, it may be added that besides the size of amyloid deposition, prominent hyperkeratosis, acanthosis
and papillomatosis, other features like increased basal layer pigmentation and pigment incontinence (both more frequent in macular amyloidosis) as well as papillomatosis and periappendageal mononuclear and neutrophilic dermal infiltrate (more frequent in lichen amyloidosis) can be used for distinction between the two histologically.
Caption: Figure 2: (a) Pseudoepitheliomatous hyperplasia with hyperkeratosis and acanthosis
nigricans (AN) shares similar "dirty" brown, confluent textural plaques, as well as nonspecific acanthosis
and papillomatosis on histopathologic examination.
Generalized malignant acanthosis
nigricans with deck-chair sign.
nigrican, raised WHR and FBS are significant parameters for insulin resistance in cases of Poly Cystic Ovary Syndrome (PCOS).
Histologically, the lesions usually show both atrophy and acanthosis
of the squamous epithelium, with variable degrees of both ortho- and parakeratosis.