were examined for the presence of thick dark velvety skin (
acanthosis nigricans).
Acanthosis nigricans associated with insulin resistance: pathophysiology and management.
Phiske, "An approach to
acanthosis nigricans," Indian Dermatology Online Journal, vol.
In univariate analysis, factors associated with having prediabetes/T2DM were obesity (OR: 5.0, 95% CI: 1.5-16.6; p = 0.008), presence of
acanthosis nigricans (OR: 7.5, 95% CI: 1.9-29.6; p = 0.004), lipohypertrophy (OR: 31.8, 95% CI: 3.6-280.9; p = 0.002), lipodystrophy (OR: 3.7, 95% CI: 1.3-10.6; p = 0.016), and exposure to indinavir for at least 6 months (OR: 3.05, 95% CI: 1.03-9.0; p = 0.044).
Acanthosis nigricans mainly affects those people who are overweight and although not a condition in itself, it can be a sign of a more serious problem, such as diabetes or cancer.
Genetic factors and clinical signifi cance of
acanthosis nigricans in obese japanese children and adolescents.
It's rare for hyperpigmentation to be a sign of illness, but in some cases, it could be linked with Addison's disease - a condition involving the adrenal glands, which also causes fatigue, weight loss, sickness, joint pain and low blood pressure ("You It's rare for hyperpigmentation to be a sign of illness, but in some cases, it could be linked with Addison's disease - a condition involving the adrenal glands, which also causes fatigue, weight loss, sickness, joint pain and low blood pressure ("You normally notice this sort of hyperpigmentation around the mouth and possibly the tongue," notes Dr Friedmann), and
acanthosis nigricans, dark, thickened patches that usually develop in armpits, groins and necks, can be a sign of underlying illness.
It's rare for hyperpigmentation to be a sign of illness, but in some cases, it could be linked with Addison's disease - a condition involving the adrenal glands, which also causes fatigue, weight loss, sickness, joint pain and low blood pressure ("You normally y notice this sort of hyperpigmentation around the mouth and possibly the tongue," notes Friedmann), and
acanthosis nigricans, dark, thickened patches that usually develop in armpits, groins and necks, can be a sign of underlying illness.
Significant trends toward smaller waist circumference and rate of
acanthosis nigricans were seen with more vigorous activity.
* Any other clinical conditions associated with insulin resistance (e g , severe obesity,
Acanthosis nigricans); or
A finding of
acanthosis nigricans in a nonobese teen is a very good indicator that they may have underlying insulin resistance.
(3,4) Differential diagnosis includes other causes of black colored esophagus with melanosis, pseudomelanosis, malignant melanoma and
acanthosis nigricans. (3,6) Treatment is often non-specific and includes fluid resuscitation, short term parenteral nutrition, gastric acid suppression (often with proton pump inhibitors) and sucralfate suspension.
