acanthosis

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acanthosis

[a‚kan′thō·səs]
(medicine)
Any thickening of the prickle-cell layer of the epidermis; associated with many skin diseases.
References in periodicals archive ?
were examined for the presence of thick dark velvety skin (acanthosis nigricans).
Acanthosis nigricans associated with insulin resistance: pathophysiology and management.
Phiske, "An approach to acanthosis nigricans," Indian Dermatology Online Journal, vol.
In univariate analysis, factors associated with having prediabetes/T2DM were obesity (OR: 5.0, 95% CI: 1.5-16.6; p = 0.008), presence of acanthosis nigricans (OR: 7.5, 95% CI: 1.9-29.6; p = 0.004), lipohypertrophy (OR: 31.8, 95% CI: 3.6-280.9; p = 0.002), lipodystrophy (OR: 3.7, 95% CI: 1.3-10.6; p = 0.016), and exposure to indinavir for at least 6 months (OR: 3.05, 95% CI: 1.03-9.0; p = 0.044).
Acanthosis nigricans mainly affects those people who are overweight and although not a condition in itself, it can be a sign of a more serious problem, such as diabetes or cancer.
It's rare for hyperpigmentation to be a sign of illness, but in some cases, it could be linked with Addison's disease - a condition involving the adrenal glands, which also causes fatigue, weight loss, sickness, joint pain and low blood pressure ("You It's rare for hyperpigmentation to be a sign of illness, but in some cases, it could be linked with Addison's disease - a condition involving the adrenal glands, which also causes fatigue, weight loss, sickness, joint pain and low blood pressure ("You normally notice this sort of hyperpigmentation around the mouth and possibly the tongue," notes Dr Friedmann), and acanthosis nigricans, dark, thickened patches that usually develop in armpits, groins and necks, can be a sign of underlying illness.
It's rare for hyperpigmentation to be a sign of illness, but in some cases, it could be linked with Addison's disease - a condition involving the adrenal glands, which also causes fatigue, weight loss, sickness, joint pain and low blood pressure ("You normally y notice this sort of hyperpigmentation around the mouth and possibly the tongue," notes Friedmann), and acanthosis nigricans, dark, thickened patches that usually develop in armpits, groins and necks, can be a sign of underlying illness.
Significant trends toward smaller waist circumference and rate of acanthosis nigricans were seen with more vigorous activity.
* Any other clinical conditions associated with insulin resistance (e g , severe obesity, Acanthosis nigricans); or
A finding of acanthosis nigricans in a nonobese teen is a very good indicator that they may have underlying insulin resistance.
(3,4) Differential diagnosis includes other causes of black colored esophagus with melanosis, pseudomelanosis, malignant melanoma and acanthosis nigricans. (3,6) Treatment is often non-specific and includes fluid resuscitation, short term parenteral nutrition, gastric acid suppression (often with proton pump inhibitors) and sucralfate suspension.