acetaminophen


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Related to acetaminophen: aspirin

acetaminophen

(əsēt'əmĭn`əfĭn), an analgesicanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
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 and fever-reducing medicine. It is an active ingredient in many over-the-counter medicines, including Tylenol and Midol. Introduced in the early 1900s, acetaminophen is a coal tar derivative that acts by interfering with the synthesis of prostaglandinsprostaglandin
, any of a group of about a dozen compounds synthesized from fatty acids in mammals as well as in lower animals. Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue.
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 and other substances necessary for the transmission of pain impulses. Although its action is similar to that of aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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, it lacks aspirin's anti-inflammatory and blood-thinning effects, is less irritating to the stomach, and can be used by people who are allergic to aspirin. Heavy use, however, has been linked to an increased incidence of liver failure, especially in heavy drinkers of alcoholic beverages and in those who are not eating enough, and overdose, especially in children, can be fatal.

acetaminophen

[ə‚sēd·ə′mēn·ə·fən]
(organic chemistry)
C8H9O2N Large monoclinic prisms with a melting point of 169-170°C; soluble in organic solvents such as methanol and ethanol; used in the manufacture of azo dyes and photographic chemicals, and as an analgesic and antipyretic.
References in periodicals archive ?
The study, published in the journal EBioMedicine, highlights the power of genomic and metabolomic profiling to better understand drug mechanisms of action and metabolism even in common drugs such as acetaminophen.
Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy," said Shanna Swan, PhD, professor of environmental and public health at Mount Sinai and the study's senior author, according to a (https://www.
Reduced Length of Stay and Hospitalization Costs Among Inpatient Bariatric Patients with Postoperative Pain Management Including Intravenous Versus Oral Acetaminophen e-Poster EP4224 assessed the impact of pain management including IV acetaminophen versus oral acetaminophen on hospital length of stay (LOS), measured by the number of days from admission to discharge; total hospitalization costs; average daily morphine equivalent dose or MED (a measure of total daily opioid consumption); and potential opioid-related complications of patients undergoing bariatric surgery starting on the day of surgery and continuing up to the third postoperative day.
Acetaminophen, such as Tylenol which is a pain reliever and a fever reducer, its intake during surgery may reduce the incidence of postoperative shivering.
The company said the Oxycodone and Acetaminophen Tablets, USP in 5 mg/325 mg and 10 mg/325 mg is the therapeutic equivalent to the reference listed drug, Percocet Tablets, 5 mg/325 mg and 10 mg/325 mg, of Vintage Pharmaceuticals, LLC.
A 2011 in vitro study, led by Schultz, found that an acetaminophen metabolite, para-aminophenol, kills mouse cortical neurons.
Some experts have suggested that the observational studies reporting a link between acetaminophen and asthma exacerbations may have been flawed by "confounding by indication," because children with asthma have more symptomatic respiratory infections than do those without asthma and use more acetaminophen for fever and malaise.
In an earlier study, it was discovered that acetaminophen also blunts positive emotions like joy.
These findings suggest other people's pain doesn't seem as big of a deal to you when you've taken acetaminophen," said Dominik Mischkowski, co-author of the study and a former Ph.
The real trouble lies in the fact that it's not always easy to notice that acetaminophen is an active ingredient in a combination medication unless you read the label carefully.
Group B was treated with acetaminophen 600 mg/kg dissolved in 16.