acetaminophen


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Related to acetaminophen: aspirin

acetaminophen

(əsēt'əmĭn`əfĭn), an analgesicanalgesic
, any of a diverse group of drugs used to relieve pain. Analgesic drugs include the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, acetaminophen, narcotic drugs such as morphine, and synthetic drugs with morphinelike action such as meperidine
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 and fever-reducing medicine. It is an active ingredient in many over-the-counter medicines, including Tylenol and Midol. Introduced in the early 1900s, acetaminophen is a coal tar derivative that acts by interfering with the synthesis of prostaglandinsprostaglandin
, any of a group of about a dozen compounds synthesized from fatty acids in mammals as well as in lower animals. Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue.
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 and other substances necessary for the transmission of pain impulses. Although its action is similar to that of aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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, it lacks aspirin's anti-inflammatory and blood-thinning effects, is less irritating to the stomach, and can be used by people who are allergic to aspirin. Heavy use, however, has been linked to an increased incidence of liver failure, especially in heavy drinkers of alcoholic beverages and in those who are not eating enough, and overdose, especially in children, can be fatal.

acetaminophen

[ə‚sēd·ə′mēn·ə·fən]
(organic chemistry)
C8H9O2N Large monoclinic prisms with a melting point of 169-170°C; soluble in organic solvents such as methanol and ethanol; used in the manufacture of azo dyes and photographic chemicals, and as an analgesic and antipyretic.
References in periodicals archive ?
Exclusion criteria were the following: patients aged < 1 year or [greater than or equal to]13 years, any renal or hepatic impairment, any neurological disorder impairing an accurate pain assessment, an allergy to acetaminophen, or lack of informed consent from the parents.
Specifically, he set out with his colleagues to explore whether acetaminophen might also reduce someone's ability to experience positive empathy.
"The only treatment available now for acetaminophen overdose must be administered early before significant liver injury occurs," said Matthew McMillin, who performed the research.
Acetaminophen Solution for Infusion is an analgesic used to treat mild to moderate pain in adult and pediatric patients two years and older, moderate to severe pain in conjunction with adjunctive opioid analgesics in the same population and for the reduction of fever in adult and pediatric patients.
Common Ingredient Each week, more than 50 million Americans use a medication that contains acetaminophen, according to the Acetaminophen Awareness Coalition.
A total of 423 patients were evaluated: 219 in the rectal acetaminophen group and 204 in the no antipyretics group.
Trouble is, many people are unaware of how prevalent acetaminophen is in the medications they use and the damage that high doses of the drug can inflict on the liver.
At the same time, "Acetaminophen certainly is no thalidomide," says Danish biologist David Kristensen, an assistant professor at the University of Copenhagen, referencing the notorious drug for morning sickness that caused severe birth defects in the 1950s and 1960s.
Acetaminophen (paracetamol) is a widely available over-the-counter (OTC) painkiller, used by 65-70 percent of pregnant women in the United States.
"Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy," said Shanna Swan, PhD, professor of environmental and public health at Mount Sinai and the study's senior author, according to a (https://www.eurekalert.org/pub_releases/2018-01/tmsh-aud010318.php) EurekAlert news release.