acetyl

(redirected from acetyl CoA)
Also found in: Dictionary, Thesaurus, Medical, Acronyms.

acetyl

[ə′sēd·əl]
(organic chemistry)
CH3CO‒ A two-carbon organic radical containing a methyl group and a carbonyl group.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
[28.] Adina-Zada A, Zeczycki TN, Attwood PV Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA. Arch Biochem Biophys 2012;519:118-30.
Adipocyte RNA was analyzed for relative expression of DIO2, a gene associated with endocrine function (LEPTIN, ADIPOQ), mitochondrial function (cell death activator (CIDEA), ATP synthase (ATP5A), and carnitine palmitoyltransferase 1B (CPT1B)), fatty acid [beta]-oxidation (acetyl CoA dehydrogenase (ACADM)), fatty acid synthesis (acetyl-CoA carboxylase (ACC2), fatty acid synthase (FASN), and diglyceride acyltransferase (DGAT)), adipocyte function (PPARgamma (PPAR[gamma])), innate immunity (NLRP3), and select proinflammatory or anti-inflammatory cytokines or chemoattractants (tumor necrosis factor alpha (TNF[alpha]), interleukin-1[beta] (IL-1[beta]), and plasminogen activator inhibitor-1 (PAI-1)).
Abbreviations: ACL, ATP citrate lyase; AMPK, AMP-activated protein kinase; Acetyl CoA, acetyl coenzyme A; ERK, extracellular signal-regulated kinase; HATs, histone acetyltransferases; HDACs, histone deacetylases; Hif1-[alpha], hypoxia inducible factor 1 alpha; MAT, methionine adenosyltransferase; MAVS; mitochondrial antiviral signaling protein; Met, methionine; mTOR, mechanistic target of rapamycin; NF[kappa]B, nuclear factor kappa B; PARP, poly(ADP-ribose) polymerase 1; SAM, S-adenosylmethionine; TCA, tricarboxylic acid cycle.
In addition to acetyl CoA, ACS1 used isobutyryl-CoA as a substrate, while ACS2 used phenylacetyl-CoA and indoleacetyl-CoA.
Novel function of calreticulin: characterization of calreticulin as a transacetylase-mediating protein acetylator independent of acetyl CoA using polyphenolic acetates.
In cells with mitochondria that contain enzymes capable of transforming acetate to acetyl CoA, such as heart, skeletal muscle, and brain, the acetate is eventually metabolized to C[O.sub.2] in the TCA cycle.
C75 is a competitive irreversible, slow-binding inhibitor of fatty acid synthase (FASN), cerulenin is suicide inhibitor of FASN, and TOFA is an allosteric inhibitor of acetyl CoA carboxylase (ACC) [8-11].
Some of the amino acids whose uptake is increased during catabolite derepression by TOR mediated signalling, such as leucine, are common intermediates of major catabolic pathways such as acetyl CoA, pyruvate, or 2-oxoglutarate.
The pyruvate generated by cholesterol oxidase activity can also get converted to acetyl CoA and acetyl choline.
C Barnett et al 1994) balancing the acetyl CoA/Coa ratio and increasing the acetyl CoA formation from piruvate (D.