acetylase


Also found in: Medical.

acetylase

[ə′sed·əl‚ās]
(biochemistry)
Any enzyme that catalyzes the formation of acetyl esters.
References in periodicals archive ?
Nrf2 inhibits LXRa-dependent hepatic lipogenesis by competing with FXR for acetylase binding.
Key event Event description Exposure IE Arsenic exposure Molecular KE7 Decreased histone acetylase or increased histone deacetylase activity KE8 Increased histone methyltransferase or decreased histone demethylase activity KE9 Decreased H3K9ac KE10 Increased H3K4me3 Individual AO3 Psychiatric and neurological disorders Key event Key event relationship Exposure IE Sources of human exposure to inorganic arsenic include drinking water, diet, air, and soils (which can contain naturally occurring arsenic or contamination from anthropogenic sources).
Boutillier, "Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration," EMBO Journal, vol.
Grigoriev et al., "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis," Cell, vol.
Moreover, p300, a transcriptional coactivator that possesses bromodominium and acetylase activity, binds to the promoter of the il17a gene in murine Th17 cells, facilitating accessibility to chromatin [106].
Ito et al., "Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma," American Journal of Respiratory and Critical Care Medicine, vol.
C-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.
(2010) HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
The use of the microarray technique evidenced a differential expression of histone acetylase enzymes between high and low ethanol-drinking B6-mice; the treatment with an HDAC inhibitor was associated with an increased ethanol intake, supporting a role for chromatin modifications in the modulation of alcohol preference [88].
In response to DDR, increased IncRNA-JADE interacts with breast cancer type 1 susceptibility protein (Brca1) and induces expression of Jade1, a major component of human acetylase binding to ORC 1 (HBO1) histone acetylation complex.
Boutillier, "Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration," The EMBO Journal, vol.22, no.24, pp.6537-6549, 2003.
Some findings are consistent with a model in which cyclin D1 serves as a key sensor and integrator of extracellular signals of cells in early to mid-G1 phase, mediating its function through binding both the CDKs and histone acetylase (p300/cAMP response element-binding protein-binding protein (CBP) and P/CAF) and histone deacetylases to modulate local chromatin structure of the genes that are involved in regulation of cell proliferation and differentiation [11,12].