acetylation


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to acetylation: methylation, acetic anhydride, acylation

acetylation

[ə‚sed·əl′ā·shən]
(organic chemistry)
The process of bonding an acetyl group onto an organic molecule.
References in periodicals archive ?
Histone acetylation and deacetylation play an important part in the nucleosome modifications process.
Histone acetylation is preferentially carried out on specific lysine: for instance, histone H3 is mainly acetylated in positions 9, 14, 18, and 23, while the lysine of histone H4 that are preferentially acetylated are in positions 5, 8, 12, and 16.
For c-fos-positive cell analysis, we used, at 24 h retention interval, EE (n = 4), SC (n = 4), PL-EE (n = 4), and PL-SC (n = 4); at 30-day retention interval, EE (n = 4), SC (n = 4), PL-EE (n = 4), and PL-SC (n = 4); for histone H3 acetylation analysis in the OFC, we used EE (n = 4), SC (n = 4), PL-EE (n = 4), and PL-SC (n = 4).
In the CAY10683 group, the acetylation of histones was further enhanced with HDAC2 reduction.
Here, we show that FA readily forms adducts with histones in cells and dramatically decreases lysine acetylation of the cytosolic histones H3 and H4.
The altered metabolism in postmortem muscle induced by HAT and HDAC inhibitors suggested that, first, HAT and HDAC, or reversible protein acetylation was involved in postmortem glycolysis; second, protein acetylatoin mediated AMPK regulation of postmortem glycolysis though further proof is needed.
Tq Dose-Dependently Increases Histone Acetylation. To assess whether histone acetylation is involved in Tq mode of action, we evaluated the acetylation of lysine 12 in histone 4 (H4 Ac-K12) by Western blotting.
For example, for histone lysine acetylation, HATs (such as p300 and CBP) transfer acetyl groups from acetyl-CoA, a key metabolic coenzyme, to the e-amino group of the lysine residue.
Acetylation null CIITA mutants lacking the signal to become nuclear bound are ubiquitinated in a K48 linked fashion leading to degradation.
Histone acetylation, the acetylation of the N-terminal tails of H3K and H4K, is a reversible dynamic process [49].