Potent acetylcholinesterase inhibitors
: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.
Donepezil, as an acetylcholinesterase inhibitor
, improves tissue perfusion and attenuates ischemia-induced muscle atrophy .
Yamatsu, "Synthesis and structure-activity relationships of acetylcholinesterase inhibitors
: 1-benzyl-4-[(5, 6-dimethoxy-1-oxoindan-2yl)methyl]piperidine hydrochloride and related compounds, " Journal of Medicinal Chemistry, vol.
Brennan, "Bioactive paper dipstick sensors for acetylcholinesterase inhibitors
based on solgel/enzyme/gold nanoparticle composites," Analyst, vol.
According to Roivant, SB742457 improves cognition in preclinical models, and preliminary preclinical data suggest a potential additive or synergistic effect when 5-HT6 antagonists are added to acetylcholinesterase inhibitors
, one of the two classes of drugs approved by the FDA for the treatment of Alzheimer's disease.
Tateishi, "Determination of donepezil, an acetylcholinesterase inhibitor
, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection," Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol.
An acetylcholinesterase inhibitor
, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
PAecilomide, a new acetylcholinesterase inhibitor
from Paecilomyces lilacinus.
This result highlights the pivotal role of acetylcholine in inflammation and provides efficacy of the essential oil from ginger and turmeric as acetylcholinesterase inhibitor
for the treatment of AD associated with inflammatory response.
Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, and donepezil, an acetylcholinesterase inhibitor
(ACEI) are the most widely accepted agents in this regard.
Nearly half of Medicare beneficiaries with Parkinson's disease were concurrently prescribed a high-potency anticholinergic medication and an acetylcholinesterase inhibitor
, with higher rates of potential prescribing errors seen among women and Hispanic patients, according to a cross-sectional analysis of Centers for Medicare & Medicaid Services data published in JAMA Neurology
Guidelines of care in many countries recommend prescribing an acetylcholinesterase inhibitor
to persons with Alzheimer's disease, if there is no contraindication for use.