The remainder of compounds tested, which included structurally related analogs such as lysergic acid, lysergic
acid amide, ergotamine, and methysergide among others, did not exhibit any measurable cross-reactivity (<0.
Infinity's programs in the inhibition of the Hsp90 chaperone system, the Hedgehog pathway and fatty
acid amide hydrolase are evidence of its innovative approach to drug discovery and development.
This financing allows us to complete a Phase II clinical trial of KDS-2000, as well as continue the development of our obesity program and our fatty
acid amide hydrolase (FAAH) inhibitor development, and other related programs," said Patrick D.
PP/wood composites made with these additives retained 90% of original flexural strength when a 75/25 blend of fatty acid ester and fatty
acid amide was added, compared with 76% retention for the reactive-extrusion coupling agents.
Infinity's programs focused on the inhibition of heat shock protein 90, phosphoinositide-3-kinase and fatty
acid amide hydrolase are evidence of its innovative approach to drug discovery and development.
Test runs on a 380-mm (rear diameter) Conex machine with 44-lb/hr capacity produced a hollow rectangular profile, 60 x 40 mm with 8 mm thick walls, using 2%
acid amide lubricant and 2% maleic anhydride-grafted polyolefin coupling agent.
With this restructuring, Infinity regains worldwide rights for its phosphoinositide-3-kinase (PI3K) program, its fatty
acid amide hydrolase (FAAH) program and its early discovery programs.
Infinity's programs in the inhibition of the Hedgehog pathway, the Hsp90 chaperone system, phosphoinositide-3-kinase and fatty
acid amide hydrolase are evidence of its innovative approach to drug discovery and development.
Infinity's programs focused on the inhibition of the Hedgehog pathway, heat shock protein 90, phosphoinositide-3-kinase and fatty
acid amide hydrolase are evidence of its innovative approach to drug discovery and development.
In addition, in October 2010, Purdue and Mundipharma exercised their right to assume worldwide development and commercialization activities for Infinity's Phase 2-ready fatty
acid amide hydrolase (FAAH) program.
Among the substances are beryllium, carbon tetrachloride, carboxylic
acid amides, lead and its inorganic compounds, and nickel.
Crodamides are fatty
acid amides, which include primary amides (erucamide, oleam-ide, behenamide and stearamide) and secondary amides (stearyl erucamide and oleyl pal-mitamide).