1), while the remaining 33% (6/18) showed acinar adenocarcinoma.
Ductal adenocarcinoma is relatively rare, is frequently associated and inter-mixed with acinar adenocarcinoma, and can be confused with microscopic mimickers.
8,9) Therefore, we investigated the use of the 34[beta]E12/p63/AMACR antibody cocktail in the diagnosis of prostate adenocarcinoma and compared the association of ductal and acinar adenocarcinoma with clinicopathological variables such as patient's age at diagnosis, cumulative Gleason score, and PSA levels.
The correlation between categorical variables with prostatic ductal and acinar adenocarcinoma was evaluated by binary logistic regression.
19) Furthermore, loss of heterozygosity is more frequently observed in IDC-P (60%) than it is in Gleason pattern 3 prostate acinar adenocarcinoma (absent), Gleason pattern 4 prostatic acinar adenocarcinoma (29%), and HGPIN (rare), (13) and loss of heterozygosity of p53 or Rb genes is more frequent in IDC-P (60% and 81%, respectively) than HGPIN (30% and 53%, respectively).
Invasive acinar adenocarcinoma may closely mimic IDC-P when it has cribriform or solid architecture (Gleason pattern 4 or 5).
Microscopic examination of the resection specimen revealed prostatic acinar adenocarcinoma
, which was unilateral, multifocal, and predominantly peripheral.
One of the most common benign mimickers of prostatic acinar adenocarcinoma
in prostate biopsies is partial atrophy (PTAT), and this differential diagnosis is a frequent reason for consultations.
Infiltrating cribriform acinar adenocarcinoma
(Gleason patterns 4 or 5, depending on whether comedonecrosis is present) closely mimics cribriform IDC-P.
The presence of nuclear hyperchromasia, with smudged chromatin and scattered pleomorphic cells (sometimes striking) beyond what is seen in acinar adenocarcinoma
, as well as the presence of lipofuscin granules, occasional intranuclear inclusions, and in the case of the seminal vesicle, a muscular wall, are all helpful clues leading toward the correct diagnosis.
The only cytology specimen in the nonresponder group was a fine-needle aspiration of the lung where the tumor was considered to be an acinar adenocarcinoma
Staining for PSA is usually negative, (23,24,26) but in some cases positivity with this marker has been reported, especially in cases in association with concomitant acinar adenocarcinoma