Development of pancreatic acinar cell
metaplasia after successful administration of omeprazole for 6 months in rats.
Histopathological examination of hematoxylin and eosin stained sections revealed an encapsulated tissue (figure 4) composed of numerous serous acinar cells
with abundant granular basophilic cytoplasm and round darkly stained eccentrically placed nucleus with multiple vacuolated cyst-like spaces (figure 5).
Miura et al., "Xanthine oxidase-mediated in response to cerulein in intracellular oxidative stress rat pancreatic acinar cells
," Pancreas, vol.
Although increased proliferation of pancreatic acinar cells
could be measured by the method of BrdU incorporation, the effects of THs on pancreatic cancer showed to be bidirectional by now according to the reports and the mechanism had been just partly explored.
Secretory granules first appeared in the cell apex of the luminal acinar cells
at this stage of prenatal life (Fig.
(38) Finally, it should be noted that parenchymal cells such as hepatocytes (39) and pancreatic acinar cells
express functional NOD1; (12-14) in the latter case, sensing of commensal organism-derived PGN by NOD1 mediates acute and chronic pancreatitis as discussed in greater detail below.
There has been increasing evidence that the nonoxidative pathway plays an important role in alcohol pathogenesis in the acinar cell
. For example, FAEEs were found to cause necrosis in pancreatic acinar cells
by inducing sustained increases in free concentrations of [Ca.sup.2+] in the cytoplasm from released intracellular stores, leading to toxicity of mitochondria and failure to produce ATP (Criddle et al.
The pancreas is composed of endocrine cells ([alpha]-cells, [beta]-cells, etc.), acinar cells
, and ductal cells, which all derive from a common progenitor expressing Pdx1 .
According to histological injury scores, the score severity of the pancreatic injury could be reflected by the scores of edema, acinar cell
necrosis, hemorrhage, inflammation, and perivascular infiltration.
We can observe dilated ductal elements and atrophy of acinar cells
Pancreatic acinar cell
carcinoma is a rare neoplasm, representing 1% to 2% of exocrine pancreatic neoplasms in adults .
The multidirectional differentiation of the neoplastic cells together with a scarcity in morphological hallmark of serous acinar cell
differentiation, as evidenced in some cases, poses a real diagnostic challenge.