Acinus

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Related to acinic: Acinic cell carcinoma

acinus

[′as·ə·nəs]
(anatomy)
The small terminal sac of an acinous gland, lined with secreting cells.
(botany)
An individual drupelet of a multiple fruit.

Acinus

 

(1) A structural and functional unit or the terminal secretory portion of the salivary, pancreatic, lacteal, sebaceous, or other saccular (alveolar) glands. The acinus is a bubble-like formation of one or more types of gland cells situated on a basement membrane and surrounded by connective tissue, capillaries, and nerve fibers. The apexes of the cells with their microvilli are directed toward the chamber of the acinus into which the secretion is discharged.

(2) A part of the respiratory apparatus in mammals that includes a section of the lung corresponding to the branches of the terminal bronchus—that is, the bronchioles, alveolar passages, and alveoli. One pulmonary lobule consists of 12–18 acini.

References in periodicals archive ?
For acinic cell carcinomas, those with a prominent tumor-associated lymphoid proliferation may actually be more indolent.
[28] Acinic cell carcinoma was diagnosed in 4 (3.50%) cases, 2 cases each were seen in parotid and submandibular glands and was seen in 3rd and 5th decade which is similar to the study conducted by Fernandes GC et al.15 Two case of adenoid cystic carcinoma were diagnosed involving the minor salivary glands which are also similar to other studies [15].
(1.) Al-Zaher N et al: Acinic cell carcinoma of the salivary glands: a literature review.
Westra, "Most nonparotid 'acinic cell carcinomas' represent mammary analog secretory carcinomas," The American Journal of Surgical Pathology, vol.
The commonest malignant tumor was mucoepidermoid carcinoma 5 (6.41%), followed by adenoid cystic carcinoma 3 (3.84%), acinic cell carcinoma 2 (2.56%), malignant mixed tumor and large duct adenocarcinoma one (1.28%) case each.
Among these patients, seven (53.8%) cases were adenoid cystic carcinoma, three (23.1%) were mucoepidermoid carcinoma and three (23.1%) were acinic cell carcinoma.
Adenocarcinomas and acinic cell carcinomas often show deletions of 6q and trisomies for chromosomes 7 or 8, in mucoepidermoid carcinomas a recurrent t(11;19)(q14-21;p12) has been described, adenoid cystic carcinomas are characterized by a recurrent t(6;9) (q21-24;p22-24) or del(6q), and carcinomas arising from pleomorphic adenomas usually have structural rearrangements resembling those in pleomorphic adenomas together with other structural or numerical abnormalities, such as polyploidization, indicating that the malignant transformation often is paralleled by cytogenetically visible clonal evolution.
We assume that an increase in NO concentration in the saliva of patients with RA can occur due to inflammatory processes acinic and ductal epithelial cells of salivary glands and, consequently, increased iNOS activity of inflamed tissue, under whose influence the NO produced in higher concentrations.
We have demonstrated that the distribution of mucous alveoli is greater than serous acini, which are mainly located at the basal membrane of acinic cells.
Minor discordance encompassed the following situations: (1) FNA diagnosis of benign/low-grade neoplasm with corresponding surgical pathology/flow cytometry demonstrating a different but also benign/low-grade neoplasm (eg, FNA diagnosis of cellular pleomorphic adenoma and corresponding surgical pathology showing basal cell adenoma); (2) FNA diagnosis of malignant neoplasm with corresponding surgical pathology/flow cytometry/cytogenetics showing a different malignant neoplasm (eg, FNA diagnosis of "salivary gland carcinoma, favor acinic cell carcinoma," and corresponding surgical pathology showing salivary duct carcinoma); and (3) nondiagnostic FNA with corresponding surgical pathology showing benign lesion with inherent low cellularity (eg, pseudocyst).
Epithelial component shows varied patterns like Cylindromatous pattern as seen in Basal cell carcinoma, Adenoid cystic carcinoma and Acinic cell carcinoma.