aconitase


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aconitase

[ə′kän·ə‚tās]
(biochemistry)
An enzyme involved in the Krebs citric acid cycle that catalyzes the breakdown of citric acid to cis-aconitic and isocitric acids.
References in periodicals archive ?
MCA's mode of action is not well characterized, but it may exert its toxicity by attenuating the mitochondrial citric acid cycle via the formation of halocitrate and the subsequent inhibition of aconitase (Frank et al.
The activities of aconitase were also reduced by 2 fold in response to frataxin deficiency.
12) Similarly, elevated superoxide levels can inhibit the enzyme aconitase, the rate-limiting step in generation of ATP via the Krebs cycle.
A regulated RNA binding protein also possesses aconitase activity.
Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats," Endocrinology, vol.
In case of low level of SOD2, the superoxide inactivates the aconitase enzyme of the TCA cycle, ceases the energy metabolism, and releases the potentially toxic iron from aconitase (Gardner et al.
Our results reveal that chronic mtDNA depletion in DRG neurons led to enhanced production of reactive oxygen species and decreases in the expression of aconitase, which catalyzes the conversion of citrate to isocitrate.
According to the detected genes for glucose metabolism, they elucidated the fungal carbohydrate metabolism pathway and postulated that the metabolites for Neocallimastix frontalis were acetate, ethanol, formate, lactate, succinate and a-ketoglutarate, which was oxidized from oxaloacetate by aconitase and isocitrate dehydrogenase.
O MFA inibe competitivamente a citrato aconitase, resultando em bloqueio do ciclo de Krebs e reducao da producao de ATP (PETERS, 1952), causando insuficiencia cardiaca.
Genetic control, linkage relationships, and mapping with aconitase and S nitrosoglutathione reductase isozyme loci.
It is confirmed by studies reported age-dependent inactivation of mito-chondrial aconitase which is the primary target of superoxide and may contribute to aging and death in yeast (Fabrizio et al.