aconitase

[ə′kän·ə‚tās]

(biochemistry)

An enzyme involved in the Krebs citric acid cycle that catalyzes the breakdown of citric acid to cis-aconitic and isocitric acids.

References in periodicals archive ?

In pancreatic cells, STZ has the ability to act as NO donor (Som et al, 2001), which prevents mitochondrial matrix aconitase activity, leading to DNA alkylation and damage increases the activity of guanylyl cyclase and the formation of cGMP, which are characteristic actions of NO.

Heteroxenia ghardaqensis Extract Protects against DNA Damage in Streptozotocin-Induced Experimental Diabetes

(17,22) In healthy prostatic epithelial cells the presence of high levels of zinc inhibit the enzyme aconitase, thereby preventing the oxidation of citrate in the Krebs' cycle.

COMPARING MR SPECTROSCOPY WITH COGNITIVE FUSION PROSTATIC BIOPSY IN THE DIAGNOSIS OF CARCINOMA PROSTATE- A PROSPECTIVE DESCRIPTIVE ANALYTIC STUDY

Curcumin attenuates Cr(VI)-induced ascites and changes in the activity of aconitase and F(1)F(0) ATPase and the ATP content in rat liver mitochondria.

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

Citrate is converted into isocitrate by the aconitase (AC), which is further converted to [alpha]-Ketoglutarate via the isocitrate dehydrogenase (IDH) producing NADH from NAD in the process.

Corrigendum to "Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced [alpha]-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species"

White, "Loss of lung mitochondrial aconitase activity due to hyperoxia in bronchopulmonary dysplasia in primates," American Journal of Physiology Lung Cellular and Molecular Physiology, vol.

The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

The mitochondrial enzymes involved in these reactions are (iso)citrate dehydrogenase (IDH2) and aconitase 2 (ACO2).

Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease

MacLeod, "Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart," Cellular and Molecular Life Sciences, vol.

Glycine Protects H9C2 Cardiomyocytes from High Glucose- and Hypoxia/Reoxygenation-Induced Injury via Inhibiting PKC[beta]2 Activation and Improving Mitochondrial Quality

These findings might have been indicative of altered glutaminolysis (the generation of [alpha]-KG from glutamine and GLU), which is a critical metabolic process for most tumors owing to aconitase mutation.

Metabolic Footprints and Molecular Subtypes in Breast Cancer

During this process, fumarate reacts with thiol groups of cysteine residues to produce S-(2-succino)-cysteine (36), which has the potential of affecting many proteins, including mitochondrial aconitase and Kelch-like ECH-associated protein-1 (KEAP1) (37).

Oncometabolites: A New Paradigm for Oncology, Metabolism, and the Clinical Laboratory

Inhibition by alloxan of mitochondrial aconitase and other enzymes associated with the citric acid cycle.

A histological study of alloxan-induced diabetes on experimental male Wistar rats

MitoNEET (mitochondrial Asn-Glu-Glu-Thr), an iron-sulfur- (Fe-S-) containing mitochondrial outer membrane protein that is involved in transferring the Fe-S clusters to the cytosolic aconitase [36], had been identified by several research groups as a binding target of the insulin sensitizer pioglitazone [37-39].

Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Huang, "Inhibitory effect of homocysteine on rat neural stem cell growth in vitro is associated with reduced protein levels and enzymatic activities of aconitase and respiratory complex III," Journal of Bioenergetics and Biomembranes, vol.

The Cardiovascular Effect of Systemic Homocysteine Is Associated with Oxidative Stress in the Rostral Ventrolateral Medulla

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