aconitase


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aconitase

[ə′kän·ə‚tās]
(biochemistry)
An enzyme involved in the Krebs citric acid cycle that catalyzes the breakdown of citric acid to cis-aconitic and isocitric acids.
References in periodicals archive ?
MCA's mode of action is not well characterized, but it may exert its toxicity by attenuating the mitochondrial citric acid cycle via the formation of halocitrate and the subsequent inhibition of aconitase (Frank et al.
A PLANT TRANSFORMATION VECTOR CONTAINING THE GENE dehD FOR THE DEVELOPMENT OF CULTIVARS RESISTANT TO MONOCHLOROACETIC ACID
The activities of aconitase were also reduced by 2 fold in response to frataxin deficiency.
Down-regulation of bioenergetics in a cellular model of Friedreich Ataxia
12) Similarly, elevated superoxide levels can inhibit the enzyme aconitase, the rate-limiting step in generation of ATP via the Krebs cycle.
Overcoming a knowledge gap to develop competent nutrigenomics practitioners
A regulated RNA binding protein also possesses aconitase activity.
Proteinas relacionadas con el metabolismo del hierro corporal
Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats," Endocrinology, vol.
Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease
The isomerization of citrate to isocitrate catalyzed by aconitase is a key step in acid metabolism.
Study on the sugar-acid ratio and relevant metabolizing enzyme activities in navel orange fruits from different eco-regions/Estudo sobre a relacao acucar-acido e atividades relevantes metabolizadoras de enzima em frutos de laranja de umbigo de diferentes ecoregioes
In case of low level of SOD2, the superoxide inactivates the aconitase enzyme of the TCA cycle, ceases the energy metabolism, and releases the potentially toxic iron from aconitase (Gardner et al.
Molecular Modeling and Phylogeny of the Manganese Superoxide Dismutase from the Camel, Camelus dromedarius
Our results reveal that chronic mtDNA depletion in DRG neurons led to enhanced production of reactive oxygen species and decreases in the expression of aconitase, which catalyzes the conversion of citrate to isocitrate.
Chronic mitochondrial DNA-deletion induces change in aconitase expression and production of ROS in DRG neurons
According to the detected genes for glucose metabolism, they elucidated the fungal carbohydrate metabolism pathway and postulated that the metabolites for Neocallimastix frontalis were acetate, ethanol, formate, lactate, succinate and a-ketoglutarate, which was oxidized from oxaloacetate by aconitase and isocitrate dehydrogenase.
Production of citrate by anaerobic fungi in the presence of co-culture methanogens as revealed by [sup.1]H NMR spectrometry
O MFA inibe competitivamente a citrato aconitase, resultando em bloqueio do ciclo de Krebs e reducao da producao de ATP (PETERS, 1952), causando insuficiencia cardiaca.
Poisoning by Amorimia spp. in ruminants/Intoxicacao por Amorimia spp. em ruminantes
Genetic control, linkage relationships, and mapping with aconitase and S nitrosoglutathione reductase isozyme loci.
Species richness and floral diversity around 'Teesta Barrage Project' in Jalpaiguri district of West Bengal, India with emphasis on invasive plants and indigenous uses
It is confirmed by studies reported age-dependent inactivation of mito-chondrial aconitase which is the primary target of superoxide and may contribute to aging and death in yeast (Fabrizio et al.
The golden root, rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast saccharomyces cerevisiae
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