aconitine


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aconitine

[ə′kän·ə‚tēn]
(pharmacology)
C34H47O11N A poisonous, white, crystalline alkaloid compound obtained from aconites such as monkshood (Aconitum napellus).
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Study of neurotoxic effects and underlying mechanisms of aconitine on cerebral cortex neuron cells.
Inhibition of ventricular arrhythmias induced by aconitine, barium chloride, myocardial ischemia, and reperfusion
The main components of Shen-Fu injection include ginsenoside (>0.8mg/mL) and aconitine (<0.1mg/mL).
Aconitine, a neurotoxin that opens TTX-sensitive Nit channels, was used to test the function of neuronal [Na.sup.+] channels in our system.
It appears that voltage-gated sodium channels are the target of many natural neurotoxins that include batrachotoxin as well as tetrodotoxin (TTX), saxitoxin (STX), conus toxins, scorpion toxins and aconitine. There are neurotoxins that modify the Na+ channel (gating modifiers) such as BTX resulting in hyperexcitably, convulsions and death and those that block Na+ channels (Na+ channel blockers), such as TTX and STX producing paralysis, respiratory failure, and also death.
Also known as wolfbane, this contains the alkaloid aconitine, which is a very powerful poison (see Figure 21-13).
Other herbs may be toxic because of possible contaminants: the Chinese herbs caowu and chuanwu used for the management of rheumatism, arthritis, bruises, and fractures may contain highly toxic potentially fatal alkaloids such as aconitine.
Furthermore, this medicinal reservoir has repeatedly contributed drugs such as ephedrine and aconitine to modern medicine in the last century.
ACONITINE - This poison is extracted from the roots of a very common plant which can be found in most garden stores.
Most of the toxicity of these HMPs is primarily derived as a result of the presence of diterpene alkaloids particularly aconitine; others include mesaconitine and hypaconitine [24].
Categories Substance with HILI Alkaloids Aconitine; febrifugine; ajmaline; vincristine Glycosides Cardiac glycosides; cyanogenic glycosides; saponins; bulbifera Toxic proteins toxin fruit; croton, castor; abrinjatropha; trichosanthes; centipede; snake venom; viper Terpene and Toosendan; spurge; Coriaria leaf; wormwood lactones leaves Tannins Gall; peel; holly leaf Heavy metals Cinnabar; realgar; light powder; litharge; vitriol; red lead Other toxic Garcinia; red fennel root; Hydnocarpus, components Pinellia ternata; daphne; melon pedicle acids; Asarum; rue; mint; Asarum forbesii; musk grass
It is the first time deadly plant sap aconitine has featured in a UK police investigation for 40 years.