aconitine


Also found in: Dictionary, Medical, Wikipedia.

aconitine

[ə′kän·ə‚tēn]
(pharmacology)
C34H47O11N A poisonous, white, crystalline alkaloid compound obtained from aconites such as monkshood (Aconitum napellus).
Mentioned in ?
References in periodicals archive ?
Inhibition of ventricular arrhythmias induced by aconitine, barium chloride, myocardial ischemia, and reperfusion
Ventricular arrhythmic models were developed using aconitine, barium chloride, and myocardial ischemia-reperfusion methods, Wenxin Granule was administered in progressively higher doses.
One of the most famous poisonings accredited to aconitine, is that of the Roman Emperor Claudius, who died suddenly in 54 AD.
A feather, previously dipped in aconitine, was used by the physician to tickle his throat to induce vomiting and save Claudius from the attempted mushroom poisoning.
It is the first time deadly plant sap aconitine has featured in a UK police investigation for 40 years.
Aconitine is contained in the roots of aconite, a blue or yellow flower with green leaves related to the buttercup.
In addition, Radix Aconiti lateralis Preparata contains very small amounts of the aconitum alkaloids, such as aconitine, mesaconitine, and hypaconitine, which are highly toxic but can be hydrolyzed to the more active but less toxic alkaloids, including benzoylaconine, benzoylmesaconine, and benzoylhypaconine that have significant anti-inflammatory and antinociceptive activities (Suzuki et al.
Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine.
3] exposure at ambient concentrations may not cause overt functional effects, but rather may produce latent or subclinical effects that appear only when the myocardium or specialized conduction system is further stressed, for example, as a result of cellular calcium loading with aconitine.
A third cohort of rats in each exposure group was challenged with aconitine to assess sensitivity to arrhythmogenic challenge.
Animals exposed to DE had increased sympathetic modulation, prolonged ventricular depolarization, and shortened repolarization periods, and they developed arrhythmia at lower doses of aconitine than controls.
Arrhythmogenesis was assessed 24 hr later by continuous intravenous infusion of aconitine, an arrhythmogenic drug, while heart rate (HR) and electrocardiogram (ECG) were monitored.