acrodermatitis enteropathica


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Related to acrodermatitis enteropathica: zinc deficiency, dermatitis herpetiformis

acrodermatitis enteropathica

[‚a·krō‚dər·mə¦tī·təs ‚en·tə·rə′pa·thə·kə]
(medicine)
An often fatal inherited disease involving inefficient intestinal absorption of zinc; readily treated by adding zinc to the diet.
References in periodicals archive ?
Edema, anaemia, hypoproteinemia, and acrodermatitis enteropathica: an uncommon initial presentation of cystic fibrosis.
Lynch et al., "Acrodermatitis enteropathica and an overview of zinc metabolism," Journal of the American Academy of Dermatology, vol.
In this case, a diagnosis of acrodermatitis enteropathica was made, which was supported by detecting low serum zinc level (31.2 p.g/dL; normal, 70-120 p.g/dL).
The immune impairment found in human diseases such as Down's syndrome, cystic fibrosis, acrodermatitis enteropathica, sickle cell anaemia characterized by zinc deficiency has been improved by zinc treatment [12, 17].
Gitschier, "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica," The American Journal of Human Genetics, vol.
The patients who had any evidence of central nervous system infection, epilepsy, metabolic seizures or those who are already on zinc therapy for any other ailment like malnutrition, diarrhea, pneumonia or acrodermatitis enteropathica were excluded.
The genetic form of the disease, idiopathic acrodermatitis enteropathica (AE), is a rare autosomal recessive disease characterized by acral and periorificial dermatitis and low serum zinc levels [2].
Zinc deficiency can be divided into two forms: congenital, also known as acrodermatitis enteropathica (first identified by Dan-bolt and Closs in 1942 (1)), and acquired form.
Proposed theories for the cause of NAE describe alterations in some metabolic factor, many of which are seen in other necrolytic erythemas, including necrolytic migratory erythema, pellagra, essential fatty acid and biotin deficiency, and acrodermatitis enteropathica. The hypothesized causes for the metabolic alteration include hypoalbuminemia, hypoaminoacidemia, low zinc level, increased glucagon, liver dysfunction, or diabetes.
Andrews, "A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity," PLoS Genetics, vol.
Acrodermatitis enteropathica: This is an autosomal recessive disease with defect in zinc absorption.
The differential diagnosis includes acrodermatitis enteropathica, essential fatty acid deficiency, annular chronic lupus erythematosus, adverse drug reactions, contact dermatitis, and various vitamin deficiencies.