acromegaly

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acromegaly

(ăk'rōmĕg`əlē), adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to gigantismgigantism,
condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance.
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Acromegaly

 

a disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy.

REFERENCES

Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv, 2nd ed. Moscow, 1955.
Rukovodstvo po klinicheskoi endokrinologii. Edited by E. A. Vasiukova. Moscow, 1958.

acromegaly

[‚ak·rō′meg·ə·lē]
(medicine)
A chronic condition in adults caused by hypersecretion of the growth hormone and marked by enlarged jaws, extremities, and viscera, accompanied by certain physiological changes.
References in periodicals archive ?
Al margen de los resultados, es preciso recordar que los niveles altos de GH en el adulto producen acromegalia y los niveles bajos deben ser sospechados en pacientes que han tenido una cirugia o tratamiento radiante por adenoma hipofisario o mas frecuentemente en pacientes adultos que presenten cansancio facil, reduccion de la capacidad fisica, debilidad muscular con reduccion de masa muscular, incremento de tejido adiposo con distribucion centripeta y alteracion del perfil lipidico, funcion cardiaca alterada, intolerancia a la glucosa con resistencia a la insulina, osteopenia, entre otros (20,21).
El excesivo crecimiento corporal da lugar a dos trastornos: la acromegalia y el gigantismo.
Dentro de las situaciones que aumentan el tamano de las estructuras del tunel del carpo se encuentran acromegalia, hipotiroidismo, embarazo, diabetes mellitus y lupus eritematoso sistemico.
Cushing + + N N-B N-B Acromegalia + + N N-B N Hiperprolactinemia + + N N-B N-A DM 2 + + N N N-A Enfermedad DHEAS LH FSH MOP HAC A A N o B 82% Tumor Adrenal MA N-A N-B 25% Tumor Ovarico A N-B N-B 80% Sind.
Tras una angustiosa peregrinacion de medico en medico, Araceli supo el nombre de su enfermedad: acromegalia.
Otras causas: la hipertension tambien se ha vinculado con hipercalcemia de cualquier origen; hiperparatiroidismo, acromegalia, hipertiroidismo, hipotiroidismo y diversos trastornos neurales causantes de un incremento en la presion intracraneal.
La acromegalia es una enfermedad causada por un tumor benigno que provoca el crecimiento anormal de las extremidades y los organos internos del organismo, asi como una transformacion en la apariencia fisica y cambios imperceptibles al interior del cuerpo, los cuales pueden conducir a la muerte.
E importante destacar que investigacoes indicam que a utilizacao abusiva e incorreta dos SA, RE e EAA leva a consequencias desde efeitos colaterais muito leves, como caibras e cansaco muscular, ate prejuizos graves, como acromegalia, sindrome metabolica, sobrecargas renais e hepaticas, alteracoes psicologicas, cardiacas e morfologicas (ginecomastia e aumento do clitoris), e ate mesmo a morte de individuos (Nogueira, Souza e Brito, 2013).
Dentro de las causas endocrinas las mas frecuentes son: el hiperaldosteronismo primario, la enfermedad tiroidea, el sindrome de Cushing y el feocromocitoma, sin mencion especial a la relacionada con la acromegalia (2), probablemente por su baja prevalencia, a que se diagnostica como hipertension arterial esencial y en el largo plazo se reconoce la enfermedad endocrina.
De estos, los que se expresaron como hiperfuncion (aumento de prolactina, acromegalia y enfermedad de Cushing) fueron los mas frecuentes (15 pacientes).
E comum encontrar SAHOS entre pacientes que apresentam obesidade, acromegalia, hipertensao arterial, problemas cardiacos, diabetes e anormalidades craniofaciais [2,5,12,13].