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(ăk'rōmĕg`əlē), adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to gigantismgigantism,
condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance.
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a disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy.


Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv, 2nd ed. Moscow, 1955.
Rukovodstvo po klinicheskoi endokrinologii. Edited by E. A. Vasiukova. Moscow, 1958.


A chronic condition in adults caused by hypersecretion of the growth hormone and marked by enlarged jaws, extremities, and viscera, accompanied by certain physiological changes.
References in periodicals archive ?
and other co-workers [20] found that IGF-1 level was high value than normal value in acromegalic patients.
This study was performed on forty-four unrelated acromegalic patients and thirty healthy subjects.
On the basis of anterior studies that have already emphasized the deficit of activation of the prefrontal cortex, whose main role concerns the executive function of the brain, our case report focuses on investigation of this aspect in acromegalic patient.
Ultrasonographic evidence of joint thickening reversibility in acromegalic patients treated with lanreotide for 12 months.
Acromegalic patients have a nasal airway or nasal trumpet inserted to assist in breathing, because most suffer from sleep apnea.
And we'd better be quick about it, before acromegalic media conglomerates run by Murdoch and Disney turn us ill into flatliners.
The approval revises the US Package Insert to allow acromegalic patient to be treated on an extended dosing interval for up to 8 weeks, through the addition of the following sentence in the labelling: "Patients who are controlled on Somatuline([R]) Depot 60 mg or 90 mg may be considered for an extended dosing interval of Somatuline([R]) Depot 120 mg every 6 or 8 weeks.
General physical examination revealed typical acromegalic features of the face [Figure 1]a, hands, and feet while a static enhanced magnetic resonance imaging (MRI) examination indicated an empty sella without pituitary adenoma.
Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF-I axis?
Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure?
A 57-year-old male patient was observed to have acromegalic features in the gastroenterology outpatient clinic in which he was seen for epigastric pain and was referred to our endocrinology outpatient clinic.
Evidence of prolonged orocecal transit time and small intestinal bacterial overgrowth in acromegalic patients.