actinomycin


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actinomycin

(ăk'tənōmī`sən), any one of a group of antibioticsantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 produced by bacteria of the genus Streptomyces. Actinomycin was the first antibiotic reported to be able to halt cancer; however, it is not widely used to treat cancers because it is highly toxic to humans, interfering with the genetic material of cells. It is mainly used as an investigative tool in cell biology.

actinomycin

[‚ak·tə·nō′mī·sən]
(microbiology)
The collective name for a large number of red chromoprotein antibiotics elaborated by various strains of Streptomyces.
References in periodicals archive ?
The cells were pretreated with 5 [micro]M GF109203X (GF) or 10 [micro]g/mL actinomycin D (ActD) for 1 h and were then treated with 1 nM TPA for 6 h (b) or 24 h (c).
2) showed similar MDR-reversal activity with other anticancer agents, such as actinomycin D, vinblastine, and paclitaxel with fold-reversals of 32.
The IVADo regimen-a pilot study with ifosfamide, vincristine, actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study of behalf of the European pediatric Soft tissue sarcoma Study Group.
Actinomycin D inhibitich of desoxiribonucleic acid-dependent synthesis of ribonucleic acid.
Regulation of secondary metabolite biosynthesis: catabolite repression of phenoxazinone synthase and actinomycin formation by glucose.
Newer agents, etoposide, ifosfamide and melphalan have been added to already existing standard regimenof vincristine, actinomycin D and cyclophosphamide (6).
The immunosuppression regimen used was the 'classic' combination of corticosteroids, azathioprine and antithymocyte globulin with the addition of cyclophosphamide or actinomycin D when severe acute rejection episodes occurred.
ACTINOMYCIN D AND ETHIDIUM BROMIDE BOUND TO CALF THYMUS DNA.
The patient was started on a vincristine, actinomycin D, and cyclophosphamide chemotherapy regimen with no significant response.
Interestingly, homeopathic remedies fail to exert any effect in the presence of actinomycin D, a DNA transcription suppressor.