actinomycin


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actinomycin

(ăk'tənōmī`sən), any one of a group of antibioticsantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 produced by bacteria of the genus Streptomyces. Actinomycin was the first antibiotic reported to be able to halt cancer; however, it is not widely used to treat cancers because it is highly toxic to humans, interfering with the genetic material of cells. It is mainly used as an investigative tool in cell biology.

actinomycin

[‚ak·tə·nō′mī·sən]
(microbiology)
The collective name for a large number of red chromoprotein antibiotics elaborated by various strains of Streptomyces.
References in periodicals archive ?
Nonetheless, the positive control actinomycin D (I[C.sub.50] =0.0022 [micro]g/ml) showed higher activity compared to N2.
(a) Real-time of TrxR1 mRNA in HUVECs treated with [H.sub.2][O.sb.2] and/or actinomycin D.
A comparable observation was reported by Ivana et al (10) who analysed the fragementation patterns of actinomycin D, demethylact D and Didemethlyact D through PSD-MALDI-TOF mass spectrometry.
A general transcription inhibitor actinomycin D normalized the downregulation of TP receptor-mediated contractions, suggesting involvement of transcriptional mechanisms.
Bergeron et al., "The IVADo regimen--a pilot study with ifosfamide, vincristine, actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study on behalf of the European Pediatric Soft Tissue Sarcoma Study Group," Cancer, vol.
The degradation rate of YFP mRNA was detected with actinomycin D treatment via qRT-PCR.
To evaluate if the enhanced level of MKP-1 protein in the presence of curcumin is a consequence of increased MKP-1 transcription, we employed Actinomycin D (ACT-D), a transcription inhibitor.
He was treated with right radical orchiectomy and adjuvant chemotherapy (three cycles of bleomycin, actinomycin, cisplatin, and vinblastine).
Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: Children's Oncology Group study D9803.
Thus, the present study aimed to evaluate the MDR-modulatory activity of the quercetin-POM conjugates 2 and 3 on the antitumor activity of the anticancer agents doxorubicin, actinomycin D, vinblastine, and paditaxel against MDR cancer cell lines.
It is known that drugs: actinomycin D, doxorubicin, the cis-platin, hydroxyurea and nitrosoureas cause diarrhea [7].